ARMCX6

ARMCX6
Identifiers
AliasesARMCX6, GASP10, armadillo repeat containing, X-linked 6, armadillo repeat containing X-linked 6
External IDsMGI: 2147993 HomoloGene: 10373 GeneCards: ARMCX6
Gene location (Human)
Chr.X chromosome (human)[1]
BandXq22.1Start101,615,118 bp[1]
End101,618,001 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

54470

278097

Ensembl

ENSG00000198960

ENSMUSG00000050394

UniProt

Q7L4S7

Q8K3A6

RefSeq (mRNA)

NM_001009584
NM_001184768
NM_019007

NM_001007578

RefSeq (protein)

NP_001009584
NP_001171697
NP_061880

NP_001007579

Location (UCSC)Chr X: 101.62 – 101.62 MbChr X: 134.75 – 134.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Armadillo repeat containing X-linked 6 is a protein that in humans is encoded by the ARMCX6 gene located on the X-chromosome.[5]

It is one of six armadillo repeats containing X-linked proteins (ARMCX1, ARMCX2, ARMCX3, ARMCX4, ARMCX5, and ARMCX6 (this protein)).

The function of this protein is unknown at this time.

Protein sequence

     1 MGRAREVGWM AAGLMIGAGA CYCVYKLTIG RDDSEKLEEE 
    41 GEEEWDDDQE LDEEEPDIWF DFETMARPWT EDGDWTEPGA 
    81 PGGTEDRPSG GGKANRAHPI KQRPFPYEHK NTWSAQNCKN 
   121 GSCVLDLSKC LFIQGKLLFA EPKDAGFPFS QDINSHLASL 
   161 SMARNTSPTP DPTVREALCA PDNLNASIES QGQIKMYINE 
   201 VCRETVSRCC NSFLQQAGLN LLISMTVINN MLAKSASDLK 
   241 FPLISEGSGC AKVQVLKPLM GLSEKPVLAG ELVGAQMLFS 
   301 FMSLFIRNGN REILLETPAP

Homology

ARMCX6 is conserved in many eukaryotic organisms.

Orthologs

taxonomic name common name NCBI entry Percentage of sequence similarity Length (AAs) comments
Homo sapiensHuman100%300armadillo repeat containing X-linked 6
Macaca mulattaRhesus monkey97.0%300PREDICTED: similar to amrmadillo repeat containing, X-linked 6 (H. sapiens)-like isoform 1
Equus caballusHorse90.0%300PREDICTED: similar to armadillo repeat containing, X-linked 6
Danio reriozebrafish84.0%301Similar to RIKEN cDNA 0610039K22
Mus musculusHouse Mouse97.7%393armadillo repeat containing, X-linked 6 (H. sapiens)-like
Bos tauruscow83.0%301armadillo repeat containing, X-linked 6
Mus musculusMouse82.0%301armadillo repeat containing, X-linked 6
Takifugu rubripesTetradontoidea66.0%818aryl hydrocarbon receptor 2C
Caenorhabditis elegansC. elegans50.0%332Serpentine Receptor, class H family member (srh-216)
Saccharomyces cerevisiaeYeast70.0%910Hul5p
Gallus gallusChicken52.0%317PREDICTED: hypothetical protein

Secondary Structure

The secondary structure of ARMCX6 is predicted to be similar to cyanase. A comparison of the two sequences is shown below.[6][7]

                          10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
ARMCX6      231 MLAKSASDLKFPLISEGSGCAKVQVLKPLMGLSEKPVLAGELVGAQM 277
1DW9_A       19 LLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKL 65
                 + +   ++ +  +  + + +   +   + +    +  +  ++++
Cyanase segment having identity with ARMCX6.

Expression

Microarray data show that ARMCX6 is highly expressed during earliest stages of spermatogenesis in mice.[8][9][10]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000198960 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050394 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: armadillo repeat containing".
  6. ↑ SDSC Biology Workbench 2.0
  7. ↑
  8. ↑ EST Profile Viewer- Human
  9. ↑ EST Profile Viewer- Mouse
  10. ↑ Su AI, Wiltshire T, Batalov S, Lapp H, et al. (April 2004). "A gene atlas of the mouse and human protein-encoding transcriptomes". Proceedings of the National Academy of Sciences of the United States of America. 101 (16): 6062–7. doi:10.1073/pnas.0400782101. PMC 395923. PMID 15075390.

Further reading

  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.


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