ARID5B

ARID5B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARID5B, DESRT, MRF-2, MRF2, AT-rich interaction domain 5B
External IDsMGI: 2175912 HomoloGene: 45872 GeneCards: ARID5B
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10q21.2Start61,901,300 bp[1]
End62,096,944 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

84159

71371

Ensembl

ENSG00000150347

ENSMUSG00000019947

UniProt

Q14865

Q8BM75

RefSeq (mRNA)

NM_001244638
NM_032199

NM_023598

RefSeq (protein)

NP_001231567
NP_115575

NP_076087

Location (UCSC)Chr 10: 61.9 – 62.1 MbChr 10: 68.09 – 68.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

AT-rich interactive domain-containing protein 5B is a protein that in humans is encoded by the ARID5B gene.[5][6][7]

Alternative names for this gene include Modulator recognition factor 23.

Genomics

The gene is located on the long arm of chromosome 10 (10q21.2) on the Watson (plus) strand. It spans 195,261 base pairs in length. It encodes a protein of predicted length and molecular weight of 1188 amino acids and 132.375 kilo Daltons respectively.

Clinical importance

Through genome wide association studies (GWAS),some of the single nucleotide polymorphisms (SNPs) located in this gene has been noticed to be significantly associated with susceptibility [8][9][10] as well as treatment outcomes [11] of childhood acute lymphoblastic leukaemia in ethnically diverse populations.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000150347 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019947 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Lahoud MH, Ristevski S, Venter DJ, Jermiin LS, Bertoncello I, Zavarsek S, Hasthorpe S, Drago J, de Kretser D, Hertzog PJ, Kola I (Aug 2001). "Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation and abnormal development of reproductive organs". Genome Research. 11 (8): 1327–34. doi:10.1101/gr.168801. PMID 11483573.
  6. ↑ Zhu L, Hu J, Lin D, Whitson R, Itakura K, Chen Y (Aug 2001). "Dynamics of the Mrf-2 DNA-binding domain free and in complex with DNA". Biochemistry. 40 (31): 9142–50. doi:10.1021/bi010476a. PMID 11478881.
  7. ↑ "Entrez Gene: ARID5B AT rich interactive domain 5B (MRF1-like)".
  8. ↑ Xu H, Yang W, Perez-Andreu V, Devidas M, Fan Y, Cheng C, et al. (May 2013). "Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations". Journal of the National Cancer Institute. 105 (10): 733–42. doi:10.1093/jnci/djt042. PMC 3691938. PMID 23512250.
  9. ↑ Treviño LR, Yang W, French D, Hunger SP, Carroll WL, Devidas M, et al. (September 2009). "Germline genomic variants associated with childhood acute lymphoblastic leukemia". Nature Genetics. 41 (9): 1001–5. doi:10.1038/ng.432. PMC 2762391. PMID 19684603.
  10. ↑ Papaemmanuil E, Hosking FJ, Vijayakrishnan J, Price A, Olver B, Sheridan E, et al. (September 2009). "Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia". Nature Genetics. 41 (9): 1006–10. doi:10.1038/ng.430. PMC 4915548. PMID 19684604.
  11. ↑ Xu H, Cheng C, Devidas M, Pei D, Fan Y, Yang W, et al. (March 2012). "ARID5B genetic polymorphisms contribute to racial disparities in the incidence and treatment outcome of childhood acute lymphoblastic leukemia". Journal of Clinical Oncology. 30 (7): 751–7. doi:10.1200/JCO.2011.38.0345. PMC 3295551. PMID 22291082.

Further reading

  • Yuan YC, Whitson RH, Liu Q, Itakura K, Chen Y (Nov 1998). "A novel DNA-binding motif shares structural homology to DNA replication and repair nucleases and polymerases". Nature Structural Biology. 5 (11): 959–64. doi:10.1038/2934. PMID 9808040.
  • Whitson RH, Huang T, Itakura K (May 1999). "The novel Mrf-2 DNA-binding domain recognizes a five-base core sequence through major and minor-groove contacts". Biochemical and Biophysical Research Communications. 258 (2): 326–31. doi:10.1006/bbrc.1999.0643. PMID 10329386.
  • Patsialou A, Wilsker D, Moran E (2005). "DNA-binding properties of ARID family proteins". Nucleic Acids Research. 33 (1): 66–80. doi:10.1093/nar/gki145. PMC 546134. PMID 15640446.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.


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