ARHGEF3

ARHGEF3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARHGEF3, GEF3, STA3, XPLN, Rho guanine nucleotide exchange factor 3
External IDsMGI: 1918954 HomoloGene: 41329 GeneCards: ARHGEF3
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3p14.3Start56,727,418 bp[1]
End57,079,329 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

50650

71704

Ensembl

ENSG00000163947

ENSMUSG00000021895

UniProt

Q9NR81

Q91X46

RefSeq (mRNA)

NM_001128615
NM_001128616
NM_001289698
NM_019555

NM_001289686
NM_001289687
NM_001289688
NM_027871

RefSeq (protein)

NP_001122087
NP_001122088
NP_001276627
NP_062455

NP_001276615
NP_001276616
NP_001276617
NP_082147

Location (UCSC)Chr 3: 56.73 – 57.08 MbChr 14: 27.11 – 27.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Rho guanine nucleotide exchange factor (GEF) 3, also known as ARHGEF3, is a human gene.[5]

Function

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to the NET1A protein.[5]

Interactions

ARHGEF3 has been shown to interact with RHOA[6] and RHOB.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000163947 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021895 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3".
  6. 1 2 Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K (Nov 2002). "XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC". J. Biol. Chem. 277 (45): 42964–72. doi:10.1074/jbc.M207401200. PMID 12221096.

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Thiesen S, Kübart S, Ropers HH, Nothwang HG (2000). "Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22". Biochem. Biophys. Res. Commun. 273 (1): 364–9. doi:10.1006/bbrc.2000.2925. PMID 10873612.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K (2003). "XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC". J. Biol. Chem. 277 (45): 42964–72. doi:10.1074/jbc.M207401200. PMID 12221096.
  • Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.


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