ARHGAP8

ARHGAP8
Identifiers
AliasesARHGAP8, BPGAP1, PP610, Rho GTPase activating protein 8
External IDsMGI: 1920417 HomoloGene: 23645 GeneCards: ARHGAP8
Gene location (Human)
Chr.Chromosome 22 (human)[1]
Band22q13.31Start44,752,558 bp[1]
End44,862,788 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

23779

73167

Ensembl

ENSG00000241484

ENSMUSG00000078954

UniProt

P85298

Q9CXP4

RefSeq (mRNA)

NM_181335
NM_001017526
NM_001198726

NM_001164627
NM_001164628
NM_001205334
NM_028455

RefSeq (protein)

NP_001017526
NP_001185655
NP_851852

NP_001158099
NP_001158100
NP_001192263
NP_082731

Location (UCSC)Chr 22: 44.75 – 44.86 MbChr 15: 84.72 – 84.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Rho GTPase-activating protein 8 is an protein that in humans is encoded by the ARHGAP8 gene.[5][6]

Function

This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. Rare read-through transcripts, containing exons from the PRR5 gene which is located immediately upstream, led to the original description of this gene as encoding a RHOGAP protein containing the proline-rich domains characteristic of PRR5 proteins. Alternatively spliced variants encoding different isoforms have been described.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000241484 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000078954 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–495. doi:10.1038/990031. PMID 10591208.
  6. 1 2 "Entrez Gene: ARHGAP8 Rho GTPase activating protein 8".

Further reading

  • Peck J, Douglas G, Wu CH, Burbelo PD (2002). "Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships". FEBS Lett. 528 (1–3): 27–34. doi:10.1016/S0014-5793(02)03331-8. PMID 12297274.
  • Shan Z, Haaf T, Popescu NC (2003). "Identification and characterization of a gene encoding a putative mouse Rho GTPase activating protein gene 8, Arhgap8". Gene. 303: 55–61. doi:10.1016/S0378-1119(02)01143-5. PMID 12559566.
  • Shang X, Zhou YT, Low BC (2003). "Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1". J. Biol. Chem. 278 (46): 45903–45914. doi:10.1074/jbc.M304514200. PMID 12944407.
  • Lua BL, Low BC (2004). "BPGAP1 interacts with cortactin and facilitates its translocation to cell periphery for enhanced cell migration". Mol. Biol. Cell. 15 (6): 2873–2883. doi:10.1091/mbc.E04-02-0141. PMC 420110. PMID 15064355.
  • Johnstone CN, Castellví-Bel S, Chang LM, Bessa X, Nakagawa H, Harada H, Sung RK, Piqué JM, Castells A, Rustgi AK (2004). "ARHGAP8 is a novel member of the RHOGAP family related to ARHGAP1/CDC42GAP/p50RHOGAP: mutation and expression analyses in colorectal and breast cancers". Gene. 336 (1): 59–71. doi:10.1016/j.gene.2004.01.025. PMID 15225876.
  • Lua BL, Low BC (2005). "Filling the GAPs in cell dynamics control: BPGAP1 promotes cortactin translocation to the cell periphery for enhanced cell migration". Biochem. Soc. Trans. 32 (Pt 6): 1110–2. doi:10.1042/BST0321110. PMID 15506981.
  • Lua BL, Low BC (2005). "Activation of EGF receptor endocytosis and ERK1/2 signaling by BPGAP1 requires direct interaction with EEN/endophilin II and a functional RhoGAP domain". J. Cell Sci. 118 (Pt 12): 2707–2721. doi:10.1242/jcs.02383. PMID 15944398.


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