ARFIP2

ARFIP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARFIP2, POR1, ADP ribosylation factor interacting protein 2
External IDsMGI: 1924182 HomoloGene: 8234 GeneCards: ARFIP2
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11p15.4Start6,474,683 bp[1]
End6,481,479 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

23647

76932

Ensembl

ENSG00000132254

ENSMUSG00000030881

UniProt

P53365

Q8K221

RefSeq (mRNA)

NM_001242854
NM_001242855
NM_001242856
NM_012402

NM_029802

RefSeq (protein)

NP_001229783
NP_001229784
NP_001229785
NP_036534

NP_084078

Location (UCSC)Chr 11: 6.47 – 6.48 MbChr 7: 105.63 – 105.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Arfaptin-2 is a protein that in humans is encoded by the ARFIP2 gene.[5][6][7]

Interactions

ARFIP2 has been shown to interact with Arf6,[8][9] ARF3,[6] ARF5[6][9] and RAC1.[5][9][10]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000132254 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030881 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 Van Aelst L, Joneson T, Bar-Sagi D (October 1996). "Identification of a novel Rac1-interacting protein involved in membrane ruffling". EMBO J. 15 (15): 3778–86. PMC 452058. PMID 8670882.
  6. 1 2 3 Kanoh H, Williger BT, Exton JH (April 1997). "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes". J Biol Chem. 272 (9): 5421–9. doi:10.1074/jbc.272.9.5421. PMID 9038142.
  7. ↑ "Entrez Gene: ARFIP2 ADP-ribosylation factor interacting protein 2 (arfaptin 2)".
  8. ↑ D'Souza-Schorey, C; Boshans R L; McDonough M; Stahl P D; Van Aelst L (September 1997). "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". EMBO J. ENGLAND. 16 (17): 5445–54. doi:10.1093/emboj/16.17.5445. ISSN 0261-4189. PMC 1170175. PMID 9312003.
  9. 1 2 3 Shin, O H; Exton J H (August 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochem. Biophys. Res. Commun. United States. 285 (5): 1267–73. doi:10.1006/bbrc.2001.5330. ISSN 0006-291X. PMID 11478794.
  10. ↑ Tarricone, C; Xiao B; Justin N; Walker P A; Rittinger K; Gamblin S J; Smerdon S J (May 2001). "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature. England. 411 (6834): 215–9. doi:10.1038/35075620. ISSN 0028-0836. PMID 11346801.

Further reading

  • D'Souza-Schorey C, Boshans RL, McDonough M, et al. (1997). "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". EMBO J. 16 (17): 5445–54. doi:10.1093/emboj/16.17.5445. PMC 1170175. PMID 9312003.
  • Tarricone C, Xiao B, Justin N, et al. (2001). "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature. 411 (6834): 215–9. doi:10.1038/35075620. PMID 11346801.
  • Shin OH, Exton JH (2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochem. Biophys. Res. Commun. 285 (5): 1267–73. doi:10.1006/bbrc.2001.5330. PMID 11478794.
  • Peters PJ, Ning K, Palacios F, et al. (2002). "Arfaptin 2 regulates the aggregation of mutant huntingtin protein". Nat. Cell Biol. 4 (3): 240–5. doi:10.1038/ncb761. PMID 11854752.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Lu L, Hong W (2004). "Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi". Mol. Biol. Cell. 14 (9): 3767–81. doi:10.1091/mbc.E03-01-0864. PMC 196566. PMID 12972563.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rangone H, Pardo R, Colin E, et al. (2005). "Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment". J. Biol. Chem. 280 (23): 22021–8. doi:10.1074/jbc.M407528200. PMID 15809304.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.


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