ANKRD23

ANKRD23
Identifiers
AliasesANKRD23, DARP, MARP3, ankyrin repeat domain 23
External IDsMGI: 1925571 HomoloGene: 14025 GeneCards: ANKRD23
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q11.2Start96,824,526 bp[1]
End96,857,934 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

200539

78321

Ensembl

ENSG00000163126

ENSMUSG00000067653

UniProt

Q86SG2

Q812A3

RefSeq (mRNA)

NM_144994

NM_153502
NM_001310521

RefSeq (protein)

NP_659431

NP_001297450
NP_705722

Location (UCSC)Chr 2: 96.82 – 96.86 MbChr 1: 36.53 – 36.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ankyrin repeat domain-containing protein 23 is a protein that in humans is encoded by the ANKRD23 gene.[5][6]

This gene is a member of the muscle ankyrin repeat protein (MARP) family and encodes a protein with four tandem ankyrin-like repeats. The protein is localized to the nucleus, functioning as a transcriptional regulator. Expression of this protein is induced during recovery following starvation.[6]

Interactions

ANKRD23 has been shown to interact with Titin[7] and MYPN.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000163126 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000067653 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Ikeda K, Emoto N, Matsuo M, Yokoyama M (Feb 2003). "Molecular identification and characterization of a novel nuclear protein whose expression is up-regulated in insulin-resistant animals". J Biol Chem. 278 (6): 3514–20. doi:10.1074/jbc.M204563200. PMID 12456686.
  6. 1 2 "Entrez Gene: ANKRD23 ankyrin repeat domain 23".
  7. 1 2 Miller, Melanie K; Bang Marie-Louise; Witt Christian C; Labeit Dietmar; Trombitas Charles; Watanabe Kaori; Granzier Henk; McElhinny Abigail S; Gregorio Carol C; Labeit Siegfried (Nov 2003). "The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules". J. Mol. Biol. England. 333 (5): 951–64. doi:10.1016/j.jmb.2003.09.012. ISSN 0022-2836. PMID 14583192.

Further reading

  • Hillier LW; Graves TA; Fulton RS; et al. (2005), "Generation and annotation of the DNA sequences of human chromosomes 2 and 4", Nature, 434 (7034): 724–31, Bibcode:2005Natur.434..724H, doi:10.1038/nature03466, PMID 15815621
  • Gerhard DS; Wagner L; Feingold EA; et al. (2004), "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)", Genome Res., 14 (10B): 2121–7, doi:10.1101/gr.2596504, PMC 528928, PMID 15489334
  • Nagueh SF; Shah G; Wu Y; et al. (2005), "Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy", Circulation, 110 (2): 155–62, doi:10.1161/01.CIR.0000135591.37759.AF, PMID 15238456
  • Ota T; Suzuki Y; Nishikawa T; et al. (2004), "Complete sequencing and characterization of 21,243 full-length human cDNAs", Nat. Genet., 36 (1): 40–5, doi:10.1038/ng1285, PMID 14702039
  • Miller MK; Bang ML; Witt CC; et al. (2003), "The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules", J. Mol. Biol., 333 (5): 951–64, doi:10.1016/j.jmb.2003.09.012, PMID 14583192
  • Strausberg RL; Feingold EA; Grouse LH; et al. (2003), "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences", Proc. Natl. Acad. Sci. U.S.A., 99 (26): 16899–903, Bibcode:2002PNAS...9916899M, doi:10.1073/pnas.242603899, PMC 139241, PMID 12477932
  • Dias Neto E; Correa RG; Verjovski-Almeida S; et al. (2000), "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags", Proc. Natl. Acad. Sci. U.S.A., 97 (7): 3491–6, Bibcode:2000PNAS...97.3491D, doi:10.1073/pnas.97.7.3491, PMC 16267, PMID 10737800
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