AMY2B

AMY2B
Identifiers
AliasesAMY2B, AMY2, AMY3, HXA, amylase, alpha 2B (pancreatic)
External IDsMGI: 3714985 HomoloGene: 134663 GeneCards: AMY2B
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p21.1Start103,553,815 bp[1]
End103,579,534 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

280

100043686

Ensembl

ENSG00000240038

ENSMUSG00000093931

UniProt

P19961

P00688

RefSeq (mRNA)

NM_020978

NM_001160151

RefSeq (protein)

NP_066188

NP_001153622

Location (UCSC)Chr 1: 103.55 – 103.58 MbChr 3: 113.31 – 113.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Alpha-amylase 2B is an enzyme that in humans is encoded by the AMY2B gene.[5][6]

Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000240038 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000093931 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Omichi K, Hase S (Jan 1994). "Identification of the characteristic amino-acid sequence for human alpha-amylase encoded by the AMY2B gene". Biochim Biophys Acta. 1203 (2): 224–9. doi:10.1016/0167-4838(93)90087-8. PMID 8268204.
  6. 1 2 "Entrez Gene: AMY2B amylase, alpha 2B (pancreatic)".

Further reading

  • Kaczmarek MJ, Rosenmund H (1977). "The action of human pancreatic and salivary isoamylases on starch and glycogen". Clin. Chim. Acta. 79 (1): 69–73. doi:10.1016/0009-8981(77)90462-4. PMID 890964.
  • Groot PC, Mager WH, Henriquez NV, et al. (1991). "Evolution of the human alpha-amylase multigene family through unequal, homologous, and inter- and intrachromosomal crossovers". Genomics. 8 (1): 97–105. doi:10.1016/0888-7543(90)90230-R. PMID 2081604.
  • Yokouchi H, Horii A, Emi M, et al. (1990). "Cloning and characterization of a third type of human alpha-amylase gene, AMY2B". Gene. 90 (2): 281–6. doi:10.1016/0378-1119(90)90191-S. PMID 2401405.
  • Gumucio DL, Wiebauer K, Caldwell RM, et al. (1988). "Concerted evolution of human amylase genes". Mol. Cell. Biol. 8 (3): 1197–205. PMC 363264. PMID 2452973.
  • Samuelson LC, Wiebauer K, Gumucio DL, Meisler MH (1988). "Expression of the human amylase genes: recent origin of a salivary amylase promoter from an actin pseudogene". Nucleic Acids Res. 16 (17): 8261–76. doi:10.1093/nar/16.17.8261. PMC 338557. PMID 2458567.
  • Tomita N, Horii A, Doi S, et al. (1989). "A novel type of human alpha-amylase produced in lung carcinoid tumor". Gene. 76 (1): 11–8. doi:10.1016/0378-1119(89)90003-6. PMID 2701942.
  • Groot PC, Bleeker MJ, Pronk JC, et al. (1989). "The human alpha-amylase multigene family consists of haplotypes with variable numbers of genes". Genomics. 5 (1): 29–42. doi:10.1016/0888-7543(89)90083-9. PMID 2788608.
  • Groot PC, Bleeker MJ, Pronk JC, et al. (1988). "Human pancreatic amylase is encoded by two different genes". Nucleic Acids Res. 16 (10): 4724. doi:10.1093/nar/16.10.4724. PMC 336663. PMID 3260028.
  • Tricoli JV, Shows TB (1984). "Regional assignment of human amylase (AMY) to p22----p21 of chromosome 1". Somat. Cell Mol. Genet. 10 (2): 205–10. doi:10.1007/BF01534909. PMID 6608795.
  • Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
  • Aughsteen AA (2001). "A comparative immunohistochemical study on amylase localization in the rat and human exocrine pancreas". Saudi medical journal. 22 (5): 410–5. PMID 11376382.
  • Koyama I, Komine S, Iino N, et al. (2001). "alpha-Amylase expressed in human liver is encoded by the AMY-2B gene identified in tumorous tissues". Clin. Chim. Acta. 309 (1): 73–83. doi:10.1016/S0009-8981(01)00501-0. PMID 11408008.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Iafrate AJ, Feuk L, Rivera MN, et al. (2004). "Detection of large-scale variation in the human genome". Nat. Genet. 36 (9): 949–51. doi:10.1038/ng1416. PMID 15286789.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.


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