ALPK1

ALPK1
Identifiers
AliasesALPK1, 8430410J10Rik, LAK, alpha kinase 1
External IDsMGI: 1918731 HomoloGene: 11849 GeneCards: ALPK1
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q25Start112,285,509 bp[1]
End112,442,620 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

80216

71481

Ensembl

ENSG00000073331

ENSMUSG00000028028

UniProt

Q96QP1

Q9CXB8

RefSeq (mRNA)

NM_001102406
NM_001253884
NM_025144

NM_027808

RefSeq (protein)

NP_001095876
NP_001240813
NP_079420

n/a

Location (UCSC)Chr 4: 112.29 – 112.44 MbChr 3: 127.67 – 127.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Alpha-protein kinase 1 is an enzyme that in humans is encoded by the ALPK1 gene.[5][6][7]

Unlike most eukaryotic kinases, alpha kinases, such as LAK, recognize phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.[supplied by OMIM][7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000073331 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028028 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Ryazanov AG, Pavur KS, Dorovkov MV (Mar 1999). "Alpha-kinases: a new class of protein kinases with a novel catalytic domain". Curr Biol. 9 (2): R43–5. doi:10.1016/S0960-9822(99)80006-2. PMID 10021370.
  6. ↑ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
  7. 1 2 "Entrez Gene: ALPK1 alpha-kinase 1".

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Yamada S, Ohira M, Horie H, et al. (2004). "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas". Oncogene. 23 (35): 5901–11. doi:10.1038/sj.onc.1207782. PMID 15221005.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Heine M, Cramm-Behrens CI, Ansari A, et al. (2005). "Alpha-kinase 1, a new component in apical protein transport". J. Biol. Chem. 280 (27): 25637–43. doi:10.1074/jbc.M502265200. PMID 15883161.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.


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