AKAP2

AKAP2
Identifiers
AliasesAKAP2, AKAP-2, AKAPKL, PRKA2, A-kinase anchoring protein 2, MISP2
External IDsMGI: 1306795 HomoloGene: 100376 GeneCards: AKAP2
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q31.3Start110,048,598 bp[1]
End110,172,512 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

11217

11641

Ensembl

ENSG00000241978

ENSMUSG00000038729

UniProt

Q9Y2D5

O54931

RefSeq (mRNA)

NM_001198656
NM_001004065
NM_001136562

NM_001035532
NM_001035533
NM_009649

RefSeq (protein)

NP_009134
NP_671492

NP_001030609
NP_001030610
NP_033779

Location (UCSC)Chr 9: 110.05 – 110.17 MbChr 4: 57.72 – 57.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

A-kinase anchor protein 2 is an enzyme that in humans is encoded by the AKAP2 gene.[5][6]

Interactions

AKAP2 has been shown to interact with PRKAR2A.[7][8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000241978 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038729 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jul 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
  6. ↑ "Entrez Gene: AKAP2 A kinase (PRKA) anchor protein 2".
  7. ↑ Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD (Apr 2003). "Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4445–50. doi:10.1073/pnas.0330734100. PMC 153575. PMID 12672969.
  8. ↑ Dong F, Feldmesser M, Casadevall A, Rubin CS (Mar 1998). "Molecular characterization of a cDNA that encodes six isoforms of a novel murine A kinase anchor protein". J. Biol. Chem. 273 (11): 6533–41. doi:10.1074/jbc.273.11.6533. PMID 9497389.

Further reading

  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Alto NM, Soderling SH, Hoshi N, et al. (2003). "Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4445–50. doi:10.1073/pnas.0330734100. PMC 153575. PMID 12672969.
  • Kammerer S, Burns-Hamuro LL, Ma Y, et al. (2003). "Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4066–71. doi:10.1073/pnas.2628028100. PMC 153049. PMID 12646697.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Hu B, Copeland NG, Gilbert DJ, et al. (2001). "The paralemmin protein family: identification of paralemmin-2, an isoform differentially spliced to AKAP2/AKAP-KL, and of palmdelphin, a more distant cytosolic relative". Biochem. Biophys. Res. Commun. 285 (5): 1369–76. doi:10.1006/bbrc.2001.5329. PMID 11478809.
  • Dong F, Feldmesser M, Casadevall A, Rubin CS (1998). "Molecular characterization of a cDNA that encodes six isoforms of a novel murine A kinase anchor protein". J. Biol. Chem. 273 (11): 6533–41. doi:10.1074/jbc.273.11.6533. PMID 9497389.


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