AGPAT9

GPAT3
Identifiers
AliasesGPAT3, AGPAT 10, AGPAT8, LPAAT-theta, MAG1, AGPAT9, HMFN0839, AGPAT10, glycerol-3-phosphate acyltransferase 3
External IDsMGI: 3603816 HomoloGene: 13099 GeneCards: GPAT3
EC number2.3.1.51
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q21.23Start83,535,914 bp[1]
End83,605,875 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

84803

231510

Ensembl

ENSG00000138678

ENSMUSG00000029314

UniProt

Q53EU6

Q8C0N2

RefSeq (mRNA)

NM_001256421
NM_001256422
NM_032717

NM_172715

RefSeq (protein)

NP_001243350
NP_001243351
NP_116106

NP_766303

Location (UCSC)Chr 4: 83.54 – 83.61 MbChr 5: 100.85 – 100.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glycerol-3-phosphate acyltransferase 3 (GPAT-3) is an enzyme that in humans is encoded by the AGPAT9 gene.[5][6][7][8] GPAT-3 is also known as:

  • 1-acylglycerol-3-phosphate O-acyltransferase 9 (AGPAT9),
  • lysophosphatidic acid acyltransferase theta (LPAAT-theta), or
  • lung cancer metastasis-associated protein 1.

Function

Glycerol-3-phosphate (G3P) acyltransferases (GPAT; EC 2.3.1.15), such as GPAM and GPAT3 (this enzyme), catalyze the initial step of de novo triacylglycerol (TAG) synthesis by converting glycerol-3-phosphate (G3P) to lysophosphatidic acid (LPA).[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000138678 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029314 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Clark HF, Gurney AL, Abaya E, et al. (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  6. 1 2 Cao J, Li JL, Li D, Tobin JF, Gimeno RE (December 2006). "Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis". Proc. Natl. Acad. Sci. U.S.A. 103 (52): 19695–700. doi:10.1073/pnas.0609140103. PMC 1702318. PMID 17170135.
  7. ↑ Tang W, Yuan J, Chen X, Gu X, Luo K, Li J, Wan B, Wang Y, Yu L (September 2006). "Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway". J. Biochem. Mol. Biol. 39 (5): 626–35. doi:10.5483/BMBRep.2006.39.5.626. PMID 17002884.
  8. ↑ "Entrez Gene: AGPAT9: 1-acylglycerol-3-phosphate O-acyltransferase 9".

Further reading

  • Tang W, Yuan J, Chen X, et al. (2006). "Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway". J. Biochem. Mol. Biol. 39 (5): 626–35. doi:10.5483/BMBRep.2006.39.5.626. PMID 17002884.
  • Yamada S, Ohira M, Horie H, et al. (2004). "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas". Oncogene. 23 (35): 5901–11. doi:10.1038/sj.onc.1207782. PMID 15221005.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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