AFTPH

AFTPH
Identifiers
AliasesAFTPH, Nbla10388, aftiphilin
External IDsMGI: 1923012 HomoloGene: 9764 GeneCards: AFTPH
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p14Start64,524,305 bp[1]
End64,593,005 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

54812

216549

Ensembl

ENSG00000119844

ENSMUSG00000049659

UniProt

Q6ULP2

Q80WT5

RefSeq (mRNA)

NM_001002243
NM_017657
NM_203437

NM_001252503
NM_001290545
NM_181411

RefSeq (protein)

NP_001002243
NP_060127
NP_982261

NP_001239432
NP_001277474
NP_852076

Location (UCSC)Chr 2: 64.52 – 64.59 MbChr 11: 20.69 – 20.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Clathrin-binding box of Aftiphilin
Identifiers
Symbol Clathrin_bdg
Pfam PF15045

Aftiphilin is a protein that in humans is encoded by the AFTPH gene.[5][6][7][8]

Aftiphilin forms a stable complex with p200 and synergin gamma.[6][7] The protein contains a clathrin box, with two identified clathrin-binding motifs, and is involved in vesicle-trafficking.[9] The protein is found in many eukaryotes.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000119844 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049659 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Mattera R, Ritter B, Sidhu SS, McPherson PS, Bonifacino JS (Feb 2004). "Definition of the consensus motif recognized by gamma-adaptin ear domains". J Biol Chem. 279 (9): 8018–28. doi:10.1074/jbc.M311873200. PMID 14665628.
  6. 1 2 Hirst J, Borner GH, Harbour M, Robinson MS (Apr 2005). "The aftiphilin/p200/gamma-synergin complex". Mol Biol Cell. 16 (5): 2554–65. doi:10.1091/mbc.E04-12-1077. PMC 1087257. PMID 15758025.
  7. 1 2 Burman JL, Wasiak S, Ritter B, de Heuvel E, McPherson PS (Apr 2005). "Aftiphilin is a component of the clathrin machinery in neurons". FEBS Lett. 579 (10): 2177–84. doi:10.1016/j.febslet.2005.03.008. PMID 15811338.
  8. ↑ "Entrez Gene: AFTPH aftiphilin".
  9. ↑ Lui-Roberts WW, Ferraro F, Nightingale TD, Cutler DF (December 2008). "Aftiphilin and gamma-synergin are required for secretagogue sensitivity of Weibel-Palade bodies in endothelial cells". Mol. Biol. Cell. 19 (12): 5072–81. doi:10.1091/mbc.E08-03-0301. PMC 2592662. PMID 18815278.

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.


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