ACYP1

ACYP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesACYP1, ACYPE, acylphosphatase 1
External IDsMGI: 1913454 HomoloGene: 11932 GeneCards: ACYP1
Gene location (Human)
Chr.Chromosome 14 (human)[1]
Band14q24.3Start75,053,221 bp[1]
End75,069,483 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

97

66204

Ensembl

ENSG00000119640

ENSMUSG00000008822

UniProt

P07311

P56376

RefSeq (mRNA)

NM_001107
NM_001302616
NM_001302617
NM_203488

NM_025421
NM_001364360
NM_001364361

RefSeq (protein)

NP_001098
NP_001289545
NP_001289546

NP_079697
NP_001351289
NP_001351290

Location (UCSC)Chr 14: 75.05 – 75.07 MbChr 12: 85.27 – 85.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Acylphosphatase-1 is an enzyme that in humans is encoded by the ACYP1 gene.[5][6][7]

Function

Acylphosphatase is a small cytosolic enzyme that catalyzes the hydrolysis of the carboxyl-phosphate bond of acylphosphates. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase, on the basis of their tissue localization. This gene encodes the erythrocyte acylphosphatase isoenzyme. Alternatively spliced transcript variants that encode different proteins were identified through data analysis.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000119640 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000008822 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Fiaschi T, Raugei G, Marzocchini R, Chiarugi P, Cirri P, Ramponi G (Jun 1995). "Cloning and expression of the cDNA coding for the erythrocyte isoenzyme of human acylphosphatase". FEBS Letters. 367 (2): 145–8. doi:10.1016/0014-5793(95)00553-L. PMID 7796909.
  6. ↑ Fiaschi T, Marzella R, Veggi D, Marzocchini R, Raugei G, Rocchi M, Ramponi G (Oct 1998). "Assignment of the human erythrocyte acylphosphatase gene (ACYP1) to chromosome band 14q24.3". Cytogenetics and Cell Genetics. 81 (3–4): 235–6. doi:10.1159/000015037. PMID 9730610.
  7. 1 2 "Entrez Gene: ACYP1 acylphosphatase 1, erythrocyte (common) type".

Further reading

  • Nassi P, Nediani C, Liguri G, Taddei N, Ramponi G (Jun 1991). "Effects of acylphosphatase on the activity of erythrocyte membrane Ca2+ pump". The Journal of Biological Chemistry. 266 (17): 10867–71. PMID 1645713.
  • Degl'Innocenti D, Berti A, Stefani M, Liguri G, Ramponi G (Aug 1990). "Immunoaffinity purification and immunoassay determination of human erythrocyte acylphosphatase". Biotechnology and Applied Biochemistry. 12 (4): 450–9. PMID 2169259.
  • Liguri G, Camici G, Manao G, Cappugi G, Nassi P, Modesti A, Ramponi G (Dec 1986). "A new acylphosphatase isoenzyme from human erythrocytes: purification, characterization, and primary structure". Biochemistry. 25 (24): 8089–94. doi:10.1021/bi00372a044. PMID 3026468.
  • Paoli P, Pazzagli L, Giannoni E, Caselli A, Manao G, Camici G, Ramponi G (Jan 2003). "A nucleophilic catalysis step is involved in the hydrolysis of aryl phosphate monoesters by human CT acylphosphatase". The Journal of Biological Chemistry. 278 (1): 194–9. doi:10.1074/jbc.M206918200. PMID 12409302.
  • Degl'Innocenti D, Marzocchini R, Malentacchi F, Ramazzotti M, Raugei G, Ramponi G (Jan 2004). "ACYP1 gene possesses two alternative splicing forms that induce apoptosis". IUBMB Life. 56 (1): 29–33. doi:10.1080/15216540310001654349. PMID 14992377.
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