ABT-436
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Routes of administration | By mouth |
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ABT-436 is an orally active, highly selective vasopressin V1B receptor antagonist which was under development by Abbott Laboratories and AbbVie for the treatment of major depressive disorder, anxiety disorders, and alcoholism but was discontinued.[1][2][3] It reached phase II clinical trials prior to the discontinuation of its development.[1][3]
See also
References
- 1 2 "ABT 436 - AdisInsight".
- ↑ Wernet, W., Hornberger, W. B., Unger, L. V., Meyer, A. H., Netz, A., Oost, T., ... & Beyerbach, A. (2008). In vitro characterization of the selective vasopressin V1b receptor antagonists ABT-436 and ABT-558. Proceedings of Society for Neuroscience, Washington DC, USA. Abstract, 560.
- 1 2 Ryan, Megan L; Falk, Daniel E; Fertig, Joanne B; Rendenbach-Mueller, Beatrice; Katz, David A; Tracy, Katherine A; Strain, Eric C; Dunn, Kelly E; Kampman, Kyle; Mahoney, Elizabeth; Ciraulo, Domenic A; Sickles-Colaneri, Laurie; Ait-Daoud, Nassima; Johnson, Bankole A; Ransom, Janet; Scott, Charles; Koob, George F; Litten, Raye Z (2016). "A Phase 2, Double-Blind, Placebo-Controlled Randomized Trial Assessing the Efficacy of ABT-436, a Novel V1b Receptor Antagonist, for Alcohol Dependence". Neuropsychopharmacology. 42 (5): 1012–1023. doi:10.1038/npp.2016.214. ISSN 0893-133X.
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