ABCA9

ABCA9
Identifiers
AliasesABCA9, EST640918, ATP binding cassette subfamily A member 9
External IDsMGI: 2386796 HomoloGene: 33332 GeneCards: ABCA9
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q24.2Start68,974,488 bp[1]
End69,061,064 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

10350

217262

Ensembl

ENSG00000154258

ENSMUSG00000041797

UniProt

Q8IUA7

Q8K449

RefSeq (mRNA)

NM_080283
NM_172386

NM_147220

RefSeq (protein)

NP_525022

NP_671753

Location (UCSC)Chr 17: 68.97 – 69.06 MbChr 11: 110.1 – 110.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ATP-binding cassette sub-family A member 9 is a protein that in humans is encoded by the ABCA9 gene.[5]

Function

This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two transmembrane domains and two nucleotide binding folds. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies ( ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This gene is a member of the ABC1 subfamily and is clustered with four other ABC1 family members on chromosome 17q24. Transcriptional expression of this gene is induced during monocyte differentiation into macrophages and is suppressed by cholesterol import.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000154258 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041797 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9".

Further reading

  • Dean M, Rzhetsky A, Allikmets R (2001). "The human ATP-binding cassette (ABC) transporter superfamily". Genome Res. 11 (7): 1156–66. doi:10.1101/gr.184901. PMID 11435397.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Mammalian Gene Collection Program Team; Strausberg, R. L.; Feingold, E. A.; Grouse, L. H.; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Piehler A, Kaminski WE, Wenzel JJ, et al. (2002). "Molecular structure of a novel cholesterol-responsive A subclass ABC transporter, ABCA9". Biochem. Biophys. Res. Commun. 295 (2): 408–16. doi:10.1016/S0006-291X(02)00659-9. PMID 12150964.
  • Allikmets R, Gerrard B, Hutchinson A, Dean M (1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Hum. Mol. Genet. 5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID 8894702.
  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
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