AAC/AAD leader

The AAC/AAD 5' leader riboswitch is a conserved RNA structure found upstream of the bacterial aminoglycosides antibiotic-resistant genes: aminoglycoside acetyl transferase (AAC) and aminoglycoside adenyl transferase (AAD). It has putative short open reading frame (ORF) that encode leader peptide upstream of the resistance gene. 75 nucleotide long sequence from the first ribosome binding site (SD1) up to the coding sequence was shown to have the regulatory role, and it was considered the minima functional RNA. Aminoglycosides bind to specific regions of AAC/AAD 5' leader and induce change in the RNA structure. The drug binding induces expression of the resistance protein. The leader RNA is widely distributed among antibiotic-resistant bacterial pathogens.^[1]

References

↑ Jia, Xu; Zhang, Jing; Sun, Wenxia; He, Weizhi; Jiang, Hengyi; Chen, Dongrong; Murchie, Alastair I. H. (2013-01-17). "Riboswitch control of aminoglycoside antibiotic resistance". Cell. 152 (1–2): 68–81. doi:10.1016/j.cell.2012.12.019. ISSN 1097-4172. PMID 23332747.

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[1] Jia, Xu; Zhang, Jing; Sun, Wenxia; He, Weizhi; Jiang, Hengyi; Chen, Dongrong; Murchie, Alastair I. H. (2013-01-17). "Riboswitch control of aminoglycoside antibiotic resistance". Cell. 152 (1–2): 68–81. doi:10.1016/j.cell.2012.12.019. ISSN 1097-4172. PMID 23332747.