8-Hydroxy-5-deazaflavin:NADPH oxidoreductase

8-hydroxy-5-deazaflavin:NADPH oxidoreductase
Identifiers
EC number 1.5.1.40
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

8-Hydroxy-5-deazaflavin:NADPH oxidoreductase (EC 1.5.1.40, 8-OH-5dFl:NADPH oxidoreductase) is an enzyme with systematic name reduced coenzyme F420:NADP+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction

reduced coenzyme F420 + NADP+ coenzyme F420 + NADPH + H+

The enzyme requires the 5-deazaflavin structure, as well as an 8-hydroxy group in the substrate.

References

  1. Eker, A.P.; Hessels, J.K.; Meerwaldt, R. (1989). "Characterization of an 8-hydroxy-5-deazaflavin:NADPH oxidoreductase from Streptomyces griseus". Biochim. Biophys. Acta. 990: 80–86. doi:10.1016/s0304-4165(89)80015-7. PMID 2492438.
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