XRN1 (gene)

XRN1
Identifiers
Aliases	XRN1, SEP1, 5'-3' exoribonuclease 1
External IDs	MGI: 891964 HomoloGene: 5894 GeneCards: XRN1
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	142,448,062 bp[1]
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[2]
End	96,057,803 bp[2]
Gene ontology
Molecular function	• DNA binding; • protein binding; • nucleic acid binding; • nuclease activity; • exonuclease activity; • hydrolase activity; • RNA binding; • G-quadruplex RNA binding; • G-quadruplex DNA binding; • 5'-3' exoribonuclease activity; • telomerase RNA binding; • 5'-3' exonuclease activity;
Cellular component	• membrane; • plasma membrane; • cell nucleus; • cytoplasm; • cytosol; • dendrite; • neuronal cell body; • synapse; • P-body;
Biological process	• regulation of mRNA stability; • rRNA catabolic process; • nuclear mRNA surveillance; • histone mRNA catabolic process; • negative regulation of translation; • response to testosterone; • cellular response to cycloheximide; • RNA phosphodiester bond hydrolysis, exonucleolytic; • cellular response to puromycin; • negative regulation of telomere maintenance via telomerase; • nuclear-transcribed mRNA catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	54464
	24127
	ENSG00000114127
	ENSMUSG00000032410
	Q8IZH2
	P97789
	NM_001042604; NM_001282857; NM_001282859; NM_019001
	NM_011916; NM_001311130
	NP_001269786; NP_001269788; NP_061874
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

5'-3' exoribonuclease 1 (Xrn1) is a protein that in humans is encoded by the XRN1 gene. Xrn1 hydrolyses RNA in the 5’ to 3’ direction.^[5]^[6]

Function

This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000114127 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032410 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Mullen TE, Marzluff WF (January 2008). "Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'". Genes & Development. 22 (1): 50–65. doi:10.1101/gad.1622708. PMC 2151014. PMID 18172165.
↑ "Entrez Gene: 5'-3' exoribonuclease 1".

Bashkirov VI, Scherthan H, Solinger JA, Buerstedde JM, Heyer WD (February 1997). "A mouse cytoplasmic exoribonuclease (mXRN1p) with preference for G4 tetraplex substrates". The Journal of Cell Biology. 136 (4): 761–73. PMC 2132493. PMID 9049243.
Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T (December 2002). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci". Rna. 8 (12): 1489–501. PMC 1370355. PMID 12515382.
Braun JE, Truffault V, Boland A, Huntzinger E, Chang CT, Haas G, Weichenrieder O, Coles M, Izaurralde E (December 2012). "A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation". Nature Structural & Molecular Biology. 19 (12): 1324–31. doi:10.1038/nsmb.2413. PMID 23142987.
Li Y, Masaki T, Yamane D, McGivern DR, Lemon SM (January 2013). "Competing and noncompeting activities of miR-122 and the 5' exonuclease Xrn1 in regulation of hepatitis C virus replication". Proceedings of the National Academy of Sciences of the United States of America. 110 (5): 1881–6. doi:10.1073/pnas.1213515110. PMC 3562843. PMID 23248316.
Li Y, Yamane D, Lemon SM (May 2015). "Dissecting the roles of the 5' exoribonucleases Xrn1 and Xrn2 in restricting hepatitis C virus replication". Journal of Virology. 89 (9): 4857–65. doi:10.1128/JVI.03692-14. PMC 4403451. PMID 25673723.
Burgess HM, Mohr I (March 2015). "Cellular 5'-3' mRNA exonuclease Xrn1 controls double-stranded RNA accumulation and anti-viral responses". Cell Host & Microbe. 17 (3): 332–44. doi:10.1016/j.chom.2015.02.003. PMC 4826345. PMID 25766294.
Ding M, Lin B, Li T, Liu Y, Li Y, Zhou X, Miao M, Gu J, Pan H, Yang F, Li T, Liu XY, Li R (April 2015). "A dual yet opposite growth-regulating function of miR-204 and its target XRN1 in prostate adenocarcinoma cells and neuroendocrine-like prostate cancer cells". Oncotarget. 6 (10): 7686–700. doi:10.18632/oncotarget.3480. PMC 4480709. PMID 25797256.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000114127 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032410 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[5] Mullen TE, Marzluff WF (January 2008). "Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'". Genes & Development. 22 (1): 50–65. doi:10.1101/gad.1622708. PMC 2151014. PMID 18172165.

[entrez-6] "Entrez Gene: 5'-3' exoribonuclease 1".

XRN1 (gene)

Function

See also

References

Further reading