3,5,7-Trioxododecanoyl-CoA synthase
| 3,5,7-Trioxododecanoyl-CoA synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.3.1.206 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
3,5,7-Trioxododecanoyl-CoA synthase (EC 2.3.1.206, TKS) is an enzyme with systematic name malonyl-CoA:hexanoyl-CoA malonyltransferase (3,5,7-trioxododecanoyl-CoA-forming).[1][2] This enzyme catalyses the following chemical reaction
- 3 malonyl-CoA + hexanoyl-CoA 3 CoA + 3,5,7-trioxododecanoyl-CoA + 3 CO2
This polyketide synthase catalyse the first step in the cannabinoids biosynthetic pathway of the plant Cannabis sativa.
References
- ↑ Taura, F.; Tanaka, S.; Taguchi, C.; Fukamizu, T.; Tanaka, H.; Shoyama, Y.; Morimoto, S. (2009). "Characterization of olivetol synthase, a polyketide synthase putatively involved in cannabinoid biosynthetic pathway". FEBS Lett. 583: 2061–2066. doi:10.1016/j.febslet.2009.05.024. PMID 19454282.
- ↑ Gagne, S.J.; Stout, J.M.; Liu, E.; Boubakir, Z.; Clark, S.M.; Page, J.E. (2012). "Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides". Proc. Natl. Acad. Sci. USA. 109 (31): 12811–12816. doi:10.1073/pnas.1200330109. PMC 3411943. PMID 22802619.
External links
- 3,5,7-trioxododecanoyl-CoA+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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