2,6-Xylidine

2,6-Xylidine
Names
IUPAC name
2,6-Dimethylaniline
Other names
  • 2,6-Dimethylbenzene-1-amine
  • 2,6-Dimethylbenzenamine
  • 2,6-Dimethylphenylamine
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.001.599
KEGG
Properties
C8H11N
Molar mass 121.18 g·mol−1
Appearance Colorless liquid
Density 0.9842 g/mL
Melting point 11.45 °C (52.61 °F; 284.60 K)
Boiling point 215 °C (419 °F; 488 K)
1.5601
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

2,6-Xylidine is an organic compound with the formula C6H3(CH3)2NH2. It is one of several isomeric xylidines. It is a colorless viscous liquid. Commercially significant derivatives are the anesthetics lidocaine, bupivacaine, mepivacaine, and etidocaine.[1]

Production and reactions

Many xylidines are prepared by nitration of a xylene followed by hydrogenation of the nitroaromatic, but this approach is not efficient for this isomer. Instead, it is prepared from by treatment of the related xylenol with ammonia in the presence of oxide catalysts.[1] Alternatively, it can be prepared from diethylketone via the cyclohexenone as shown.

Other

2,6-Xylidine is the precursor to the NHC ligand IXyl.[2]

References

  1. 1 2 M. Meyer (2012). "Xylidines". Ullmann's Encylclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a28_455.
  2. ↑ Ison, Elon A.; Ison, Ana (2012). "Synthesis of Well-Defined CopperN-Heterocyclic Carbene Complexes and Their Use as Catalysts for a "Click Reaction": A Multistep Experiment That Emphasizes the Role of Catalysis in Green Chemistry". Journal of Chemical Education. 89 (12): 1575. Bibcode:2012JChEd..89.1575I. doi:10.1021/ed300243s.
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