(''S'')-norcoclaurine synthase

(S)-norcoclaurine synthase
Identifiers
EC number 4.2.1.78
CAS number 79122-01-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a (S)-norcoclaurine synthase (EC 4.2.1.78) is an enzyme that catalyzes the chemical reaction

4-hydroxyphenylacetaldehyde + 4-(2-aminoethyl)benzene-1,2-diol (S)-norcoclaurine + H2O

Thus, the two substrates of this enzyme are 4-hydroxyphenylacetaldehyde and 4-(2-aminoethyl)benzene-1,2-diol, whereas its two products are (S)-norcoclaurine and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 4-hydroxyphenylacetaldehyde hydro-lyase [adding dopamine (S)-norcoclaurine-forming]. Other names in common use include (S)-norlaudanosoline synthase, and 4-hydroxyphenylacetaldehyde hydro-lyase (adding dopamine). This enzyme participates in benzylisoquinoline alkaloid biosynthesis.

References

    • Stadler R, Zenk MH (1990). "A revision of the generally accepted pathway for the biosynthesis of the benzyltetrahydroisoquinoline reticuline". Liebigs Ann. Chem.: 555&ndash, 562.
    • Stadler R, Kutchan TM, Zenk MH (1989). "(S)-Norcoclaurine is the central intermediate in benzylisoquinoline alkaloid biosynthesis". Phytochemistry. 28 (4): 1083&ndash, 1086. doi:10.1016/0031-9422(89)80187-6.
    • Samanani N, Facchini PJ (2002). "Purification and characterization of norcoclaurine synthase. The first committed enzyme in benzylisoquinoline alkaloid biosynthesis in plants". J. Biol. Chem. 277 (37): 33878&ndash, 83. doi:10.1074/jbc.M203051200. PMID 12107162.
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