retrosynthesis

English
Retrosynthesis of phenylacetic acid

Etymology

From retro- +‎ synthesis.

Noun

retrosynthesis (countable and uncountable, plural retrosyntheses)

  1. (organic chemistry) The prediction of precursors (intermediates and reactants), given the products of a synthesis reaction.
    • 1983, Francis A. Carey, Richard J. Sundberg, Advanced Organic Chemistry: Reactions and synthesis, Plenum Press, page 578,
      The retrosyntheses shown in Scheme 11.11 correspond to the syntheses in Schemes 11.12 and 11.13.
    • 1991, Australian Journal of Chemistry, Volume 44, CSIRO, page 1294,
      The retrosyntheses shown in Scheme 2 lead directly to acetylene-type retrons (14)-(16) (path a) or implicate the use of Dewar o-xylylene (17) (path b) and the smaller retrons (18)-(20); the latter path was the route we elected to pursue (Scheme 3).
    • 2007, Helmut Cölfen, Bio-inspired Mineralization Using Hydrophilic Polymers, Kensuke Naka (editor), Biomineralization II: Mineralization Using Synthetic Polymers and Templates, Springer, page 25,
      For example, the above mentioned retrosynthesis of nacre [132] is as much bio-inspired as is the crystallization in presence of hydrophilic polymers [44], although in the first case, the original biomineral structure is reproduced, whereas in the latter case, no biomineral is reproduced but complex crystal morphologies are obtained.

Synonyms
  • (prediction of precursors): retrosynthetic analysis

Derived terms

Translations

See also

Further reading
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