phosphodegron

English

Etymology

phospho- +‎ degron

Noun

phosphodegron (plural phosphodegrons)

  1. A phosphorylated degron
    • 2015 October 27, “Loss of Nek11 Prevents G2/M Arrest and Promotes Cell Death in HCT116 Colorectal Cancer Cells Exposed to Therapeutic DNA Damaging Agents”, in PLOS ONE‎, DOI:10.1371/journal.pone.0140975:
      Activated Nek11 is capable of phosphorylating Cdc25A on sites within a phosphodegron that promotes recruitment of β-TrCP. This, in turn, leads to ubiquitin-mediated degradation of Cdc25A and cell cycle arrest [11 –13 ].
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