pharmacomodulation

English

Etymology

pharmaco- +‎ modulation

Noun

pharmacomodulation (countable and uncountable, plural pharmacomodulations)

  1. The modification of existing pharmaceuticals by replacing substituents etc
    • 2015 August 14, “Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells”, in PLOS ONE‎, DOI:10.1371/journal.pone.0134793:
      Interestingly, the p-chloro- and p-trifluoromethyl-phenyl monophenols 10 and 11 retained activity (EC 50 = 4.0 ± 1.4 μM and 12.4 ± 6.9 μM, respectively) with an excellent selectivity versus proliferating TG1 GSCs, suggesting that pharmacomodulation is possible at this position.
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