keratorhexis

kerato- +‎ rhexis

keratorhexis (uncountable)

1. (medicine) Rupture of the cornea.
   • 1955, Charles I. Thomas, The cornea, page 249:

     This area then was flattened out near the sclera. It was not cone-shaped as in keratoconus, but cylindrical. In differential diagnosis Jauernig considered keratoconus, keratectasia and keratorhexis.

   • 2004 October, Udo Vanhoefer, Mitra Tewes, Federico Rojo, Olaf Dirsch, Norbert Schleucher, Oliver Rosen, Joachim Tillner, Andreas Kovar, Ada H. Braun, Tanja Trarbach, Siegfried Seeber, Andreas Harstrick, & José Baselga, “Phase I study of the humanized antiepidermal growth factor receptor monoclonal antibody EMD72000 in patients with advanced solid tumors that express the epidermal growth factor receptor”, in Journal of Clinical Oncology:

     One patient experienced conjunctivitis-induced keratorhexis after multiple administrations of EMD72000 at DL 3 (1,200 mg), which resolved within 1 week after symptomatic treatment.

   • 2011 May, C. D. Weekes, P. LoRusso, V. Ramakrishnan, L. M. Shih, W. C. Darbonne, P. Hegde, Y. Xin, R. Yu, H. Xiang, R. K. Brachmann, & A. Patnaik, “A phase Ib study for MNRP1685A (anti-NRP1) administered intravenously with bevacizumab with or without paclitaxel to patients with advanced solid tumors”, in Journal of Clinical Oncology, volume 29, number 15:

     Treatment-related grade 3-5 adverse events (AEs; cut-off date 11/23/10) included 1 sudden death, unknown etiology, at Day 7 in Arm A (36 mg/kg), neutropenia (n=4, all Arm B), proteinuria (n=3), thrombocytopenia (n=2), hypertension (n=2), and one each of fatigue, keratorhexis, and peripheral edema.