Zinc finger protein 426

Function

Kaposi's sarcoma-associated herpesvirus (KSHV) can be reactivated from latency by the viral protein RTA. The protein encoded by this gene is a zinc finger transcriptional repressor that interacts with RTA to modulate RTA-mediated reactivation of KSHV. While the encoded protein can repress KSHV reactivation, RTA can induce degradation of this protein through the ubiquitin-proteasome pathway to overcome the repression. Several transcript variants encoding different isoforms have been found for this gene.

References
  1. GRCh38: Ensembl release 89: ENSG00000130818 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000059475 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Zinc finger protein 426". Retrieved 2016-01-28.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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