ZRF1

DnaJ homolog subfamily C member 2 is a protein that in humans is encoded by the DNAJC2 gene.[5][6]

DNAJC2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDNAJC2, MPHOSPH11, MPP11, ZRF1, ZUO1, DnaJ heat shock protein family (Hsp40) member C2
External IDsOMIM: 605502 MGI: 99470 HomoloGene: 31656 GeneCards: DNAJC2
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7q22.1Start103,312,289 bp[1]
End103,344,830 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

27000

22791

Ensembl

ENSG00000105821

ENSMUSG00000029014

UniProt

Q99543

P54103

RefSeq (mRNA)

NM_001129887
NM_014377
NM_001362667
NM_001362668

NM_009584

RefSeq (protein)

NP_001123359
NP_055192
NP_001349596
NP_001349597

NP_033610

Location (UCSC)Chr 7: 103.31 – 103.34 MbChr 5: 21.76 – 21.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000105821 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029014 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Matsumoto-Taniura N, Pirollet F, Monroe R, Gerace L, Westendorf JM (Jan 1997). "Identification of novel M phase phosphoproteins by expression cloning". Mol Biol Cell. 7 (9): 1455–69. doi:10.1091/mbc.7.9.1455. PMC 275994. PMID 8885239.
  6. "Entrez Gene: ZRF1 zuotin related factor 1".

Further reading


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