ZHX2

Zinc fingers and homeoboxes protein 2 is a protein that in humans is encoded by the ZHX2 gene.[5][6][7]

ZHX2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesZHX2, AFR1, RAF, zinc fingers and homeoboxes 2
External IDsOMIM: 609185 MGI: 2683087 HomoloGene: 8968 GeneCards: ZHX2
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8q24.13Start122,781,655 bp[1]
End122,974,510 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

22882

387609

Ensembl

ENSG00000178764

ENSMUSG00000071757

UniProt

Q9Y6X8

Q8C0C0

RefSeq (mRNA)

NM_014943
NM_001362797

NM_199449

RefSeq (protein)

NP_055758
NP_001349726

NP_955520

Location (UCSC)Chr 8: 122.78 – 122.97 MbChr 15: 57.69 – 57.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family.[7]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000178764 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000071757 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
  6. Kawata H, Yamada K, Shou Z, Mizutani T, Yazawa T, Yoshino M, Sekiguchi T, Kajitani T, Miyamoto K (Jul 2003). "Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor". Biochem J. 373 (Pt 3): 747–57. doi:10.1042/BJ20030171. PMC 1223552. PMID 12741956.
  7. "Entrez Gene: ZHX2 zinc fingers and homeoboxes 2".

Further reading

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