ZFPM1

ZFPM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2XU7
Identifiers
Aliases	ZFPM1, FOG, FOG1, ZC2HC11A, ZNF408, ZNF89A, zinc finger protein, FOG family member 1
External IDs	OMIM: 601950 MGI: 1095400 HomoloGene: 7606 GeneCards: ZFPM1
Gene location (Human)
Chr.	Chromosome 16 (human)[1]
End	88,537,031 bp[1]
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)[2]
End	122,337,251 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• DNA binding; • RNA polymerase II transcription factor binding; • transcription factor binding; • metal ion binding; • RNA polymerase II activating transcription factor binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • GO:0001948 protein binding; • nucleic acid binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	• cytoplasm; • transcription factor complex; • transcriptional repressor complex; • nucleoplasm; • cell nucleus;
Biological process	• megakaryocyte development; • megakaryocyte differentiation; • negative regulation of mast cell differentiation; • negative regulation of interleukin-4 biosynthetic process; • negative regulation of fat cell differentiation; • regulation of transcription, DNA-templated; • homeostasis of number of cells; • transcriptional activation by promoter-enhancer looping; • positive regulation of interferon-gamma biosynthetic process; • ventricular septum morphogenesis; • outflow tract morphogenesis; • platelet formation; • blood coagulation; • cardiac muscle tissue morphogenesis; • negative regulation of transcription from RNA polymerase II promoter; • negative regulation of protein binding; • transcription, DNA-templated; • regulation of chemokine production; • atrial septum morphogenesis; • heart development; • atrioventricular valve morphogenesis; • granulocyte differentiation; • embryonic hemopoiesis; • regulation of definitive erythrocyte differentiation; • T-helper cell lineage commitment; • primitive erythrocyte differentiation; • mitral valve formation; • tricuspid valve formation; • definitive erythrocyte differentiation; • positive regulation of transcription from RNA polymerase II promoter; • erythrocyte differentiation; • regulation of megakaryocyte differentiation; • regulation of transcription from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
	161882
	22761
	ENSG00000179588
	ENSMUSG00000049577
	Q8IX07
	O35615
	NM_153813
	NM_009569
	NP_722520
	NP_033595
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein ZFPM1 also known as friend of GATA protein 1 or FOG1 is a protein that in humans is encoded by the ZFPM1 gene.[5] It is a cofactor of the GATA1 transcription factor.

References

GRCh38: Ensembl release 89: ENSG00000179588 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000049577 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: ZFPM1 zinc finger protein, multitype 1".

Tsang AP, Visvader JE, Turner CA, et al. (1997). "FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation". Cell. 90 (1): 109–19. doi:10.1016/S0092-8674(00)80318-9. PMID 9230307.
Turner J, Crossley M (1998). "Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators". EMBO J. 17 (17): 5129–40. doi:10.1093/emboj/17.17.5129. PMC 1170841. PMID 9724649.
Mehaffey MG, Newton AL, Gandhi MJ, et al. (2001). "X-linked thrombocytopenia caused by a novel mutation of GATA-1". Blood. 98 (9): 2681–8. doi:10.1182/blood.V98.9.2681. PMID 11675338.
Yu C, Niakan KK, Matsushita M, et al. (2002). "X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction". Blood. 100 (6): 2040–5. doi:10.1182/blood-2002-02-0387. PMC 2808424. PMID 12200364.
Freson K, Thys C, Wittewrongel C, et al. (2003). "Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions". Hum. Genet. 112 (1): 42–9. doi:10.1007/s00439-002-0832-1. PMID 12483298.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Liew CK, Simpson RJ, Kwan AH, et al. (2005). "Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction". Proc. Natl. Acad. Sci. U.S.A. 102 (3): 583–8. doi:10.1073/pnas.0407511102. PMC 545545. PMID 15644435.
Vannucchi AM, Pancrazzi A, Guglielmelli P, et al. (2005). "Abnormalities of GATA-1 in megakaryocytes from patients with idiopathic myelofibrosis". Am. J. Pathol. 167 (3): 849–58. doi:10.1016/S0002-9440(10)62056-1. PMC 1698737. PMID 16127162.
Yang HY, Kim SH, Kim SH, et al. (2007). "The suppression of zfpm-1 accelerates the erythropoietic differentiation of human CD34+ cells". Biochem. Biophys. Res. Commun. 353 (4): 978–84. doi:10.1016/j.bbrc.2006.12.155. PMID 17207461.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000179588 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049577 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ZFPM1 zinc finger protein, multitype 1".

ZFPM1

References

Further reading