Zinc finger homeobox 2

ZFHX2
Identifiers
Aliases	ZFHX2, ZFH-5, ZNF409, ZFH5, MARSIS, zinc finger homeobox 2
External IDs	OMIM: 617828 MGI: 2686934 HomoloGene: 52657 GeneCards: ZFHX2
Gene location (Human)
Chr.	Chromosome 14 (human)[1]
End	23,556,192 bp[1]
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)[2]
End	55,092,324 bp[2]
Gene ontology
Molecular function	• sequence-specific DNA binding; • DNA binding; • zinc ion binding; • metal ion binding; • nucleic acid binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0000975 transcription regulatory region DNA binding;
Cellular component	• cell nucleus;
Biological process	• adult behavior; • regulation of transcription, DNA-templated; • transcription, DNA-templated; • regulation of transcription from RNA polymerase II promoter; • negative regulation of transcription from RNA polymerase II promoter; • positive regulation of transcription, DNA-templated; • regulation of sensory perception of pain;
	Sources:Amigo / QuickGO
Orthologs
	85446
	239102
	ENSG00000136367
	ENSMUSG00000040721
	Q9C0A1
	Q2MHN3
	NM_033400
	NM_001039198
	NP_207646
	NP_001034287
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger homeobox 2 is a protein that in humans is encoded by the ZFHX2 gene.[5] It has been implicated in pain insensitivity.[6]

References

GRCh38: Ensembl release 89: ENSG00000136367 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000040721 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Zinc finger homeobox 2".
Habib AM, Matsuyama A, Okorokov AL, Santana-Varela S, Bras JT, Aloisi AM, et al. (December 2017). "A novel human pain insensitivity disorder caused by a point mutation in ZFHX2" (PDF). Brain. 141 (2): 365–376. doi:10.1093/brain/awx326. PMC 5837393. PMID 29253101.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.