XPO6

Exportin-6 is a protein that in humans is encoded by the XPO6 gene.[5][6]

XPO6
Identifiers
AliasesXPO6, EXP6, RANBP20, exportin 6
External IDsOMIM: 608411 MGI: 2429950 HomoloGene: 12544 GeneCards: XPO6
Gene location (Human)
Chr.Chromosome 16 (human)[1]
Band16p12.1Start28,097,979 bp[1]
End28,211,920 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

23214

74204

Ensembl

ENSG00000169180

ENSMUSG00000000131

UniProt

Q96QU8

Q924Z6

RefSeq (mRNA)

NM_001270940
NM_015171

NM_028816
NM_001311143

RefSeq (protein)

NP_001257869
NP_055986

NP_001298072
NP_083092

Location (UCSC)Chr 16: 28.1 – 28.21 MbChr 7: 126.1 – 126.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Exportins, such as XPO6, recruit cargo in the nucleoplasm in the presence of Ran-GTP and form ternary export complexes. These complexes are transported through nuclear pore complexes to the cytoplasm, where GTP is hydrolyzed and the export complex is disassembled.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000169180 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000000131 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Stuven T, Hartmann E, Gorlich D (Oct 2003). "Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes". EMBO J. 22 (21): 5928–40. doi:10.1093/emboj/cdg565. PMC 275422. PMID 14592989.
  6. "Entrez Gene: XPO6 exportin 6".

Further reading

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