WIPI protein family

The WIPI protein family (WD-repeat protein Interacting with PhosphoInositides) is an evolutionarily conserved family of proteins.[1] WIPI proteins contain a WD repeat domain that folds into a 7-bladed beta-propeller that functions in autophagy,[1] and contain a conserved motif for interaction with phospholipids.[2]

Members of this family include:

ProteinGeneAliasesYeast
WIPI-1WIPI1WIPI49, FLJ10055Atg18
WIPI-2WIPI2Svp1a, DKFZP434J154 WIPI49-like protein 2Atg21
WIPI-3WDR45L628 protein, WIPI49-like protein
WIPI-4WDR45JM5 protein, WDRX1

References

  1. Proikas-Cezanne T, Waddell S, Gaugel A, Frickey T, Lupas A, Nordheim A (December 2004). "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy". Oncogene. 23 (58): 9314–25. doi:10.1038/sj.onc.1208331. PMID 15602573.
  2. "Entrez Gene: WIPI2 WD repeat domain, phosphoinositide interacting 2".


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