V-set and immunoglobulin domain containing 4
V-set and immunoglobulin domain containing 4 is a protein that in humans is encoded by the VSIG4 gene.[5]
Function
This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants.
References
- GRCh38: Ensembl release 89: ENSG00000155659 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000044206 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: V-set and immunoglobulin domain containing 4". Retrieved 2016-06-13.
Further reading
- Helmy KY, Katschke KJ, Gorgani NN, Kljavin NM, Elliott JM, Diehl L, Scales SJ, Ghilardi N, van Lookeren Campagne M (2006). "CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens". Cell. 124 (5): 915–27. doi:10.1016/j.cell.2005.12.039. PMID 16530040.
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