VPS4B

Vacuolar protein sorting-associated protein 4B is a protein that in humans is encoded by the VPS4B gene.[5][6]

VPS4B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesVPS4B, SKD1, SKD1B, VPS4-2, MIG1, vacuolar protein sorting 4 homolog B
External IDsOMIM: 609983 MGI: 1100499 HomoloGene: 37976 GeneCards: VPS4B
Gene location (Human)
Chr.Chromosome 18 (human)[1]
Band18q21.33Start63,389,190 bp[1]
End63,422,483 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9525

20479

Ensembl

ENSG00000119541

ENSMUSG00000009907

UniProt

O75351

P46467

RefSeq (mRNA)

NM_004869

NM_009190

RefSeq (protein)

NP_004860
NP_004860.2

NP_033216

Location (UCSC)Chr 18: 63.39 – 63.42 MbChr 1: 106.76 – 106.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the AAA proteins family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein.

In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000119541 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000009907 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Scheuring S, Rohricht RA, Schoning-Burkhardt B, Beyer A, Muller S, Abts HF, Kohrer K (Sep 2001). "Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking". J Mol Biol. 312 (3): 469–80. doi:10.1006/jmbi.2001.4917. PMID 11563910.
  6. "Entrez Gene: VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae)".

Further reading

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