VCX

Variable charge X-linked protein 1 is a protein that in humans is encoded by the VCX gene.[3][4][5]

VCX
Identifiers
Aliases	VCX, VCX-10r, VCX-B1, VCX1, VCX10R, VCXB1, variable charge, X-linked, variable charge X-linked
External IDs	OMIM: 300229 HomoloGene: 88395 GeneCards: VCX
Gene location (Human) Chr. X chromosome (human)[1] Band Xp22.31 Start 7,842,262 bp[1] End 7,844,143 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • chromatin binding Cellular component • nucleolus • cell nucleus Biological process • ribosome assembly • chromatin organization • spermatogenesis • brain development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26609	n/a
Ensembl	ENSG00000182583	n/a
UniProt	Q9H320	n/a
RefSeq (mRNA)	NM_013452	n/a
RefSeq (protein)	NP_038480	n/a
Location (UCSC)	Chr X: 7.84 – 7.84 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 10 repeats of the 30-bp unit.[5]