VAV3

Guanine nucleotide exchange factor VAV3 is a protein that in humans is encoded by the VAV3 gene.[5]

VAV3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D86
Identifiers
Aliases	VAV3, vav guanine nucleotide exchange factor 3
External IDs	OMIM: 605541 MGI: 1888518 HomoloGene: 38143 GeneCards: VAV3
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.3 Start 107,571,161 bp[1] End 107,965,180 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F3 Start 109,340,653 bp[2] End 109,685,698 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • metal ion binding • epidermal growth factor receptor binding • GTPase activator activity • SH3/SH2 adaptor activity • Rac guanyl-nucleotide exchange factor activity • guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity Cellular component • cytoplasm • cytosol • cell membrane Biological process • angiogenesis • Fc-gamma receptor signaling pathway involved in phagocytosis • intracellular signal transduction • ephrin receptor signaling pathway • lamellipodium assembly • regulation of Rho protein signal transduction • positive regulation of phosphatidylinositol 3-kinase activity • vascular endothelial growth factor receptor signaling pathway • small GTPase mediated signal transduction • B cell receptor signaling pathway • cell projection assembly • Fc-epsilon receptor signaling pathway • positive regulation of apoptotic process • integrin-mediated signaling pathway • cellular response to DNA damage stimulus • regulation of cell size • regulation of small GTPase mediated signal transduction • cell migration • response to drug • platelet activation • vesicle fusion • positive regulation of cell adhesion • positive regulation of B cell proliferation • neutrophil chemotaxis • regulation of GTPase activity • positive regulation of signal transduction • positive regulation of GTPase activity • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10451	57257
Ensembl	ENSG00000134215	ENSMUSG00000033721
UniProt	Q9UKW4	Q9R0C8
RefSeq (mRNA)	NM_001079874 NM_006113	NM_020505 NM_146139 NM_001378987
RefSeq (protein)	NP_001073343 NP_006104	NP_065251 NP_666251 NP_001365916
Location (UCSC)	Chr 1: 107.57 – 107.97 Mb	Chr 3: 109.34 – 109.69 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[5]