VAMP4

Vesicle-associated membrane protein 4 is a protein that in humans is encoded by the VAMP4 gene.[5][6]

VAMP4
Identifiers
AliasesVAMP4, VAMP-4, VAMP24, vesicle associated membrane protein 4
External IDsOMIM: 606909 MGI: 1858730 HomoloGene: 37847 GeneCards: VAMP4
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q24.3Start171,700,160 bp[1]
End171,742,074 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8674

53330

Ensembl

ENSG00000117533

ENSMUSG00000026696

UniProt

O75379

O70480

RefSeq (mRNA)

NM_001185127
NM_003762
NM_201994

NM_016796
NM_001347125
NM_001356526
NM_001356527

RefSeq (protein)

NP_001172056
NP_003753

NP_001334054
NP_058076
NP_001343455
NP_001343456

Location (UCSC)Chr 1: 171.7 – 171.74 MbChr 1: 162.57 – 162.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport.[6]

Interactions

VAMP4 has been shown to interact with AP1M1,[7] STX6[8] and STX16.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000117533 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026696 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Advani RJ, Bae HR, Bock JB, Chao DS, Doung YC, Prekeris R, Yoo JS, Scheller RH (Apr 1998). "Seven novel mammalian SNARE proteins localize to distinct membrane compartments". The Journal of Biological Chemistry. 273 (17): 10317–24. doi:10.1074/jbc.273.17.10317. PMID 9553086.
  6. "Entrez Gene: VAMP4 vesicle-associated membrane protein 4".
  7. Hinners I, Wendler F, Fei H, Thomas L, Thomas G, Tooze SA (Dec 2003). "AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1". EMBO Reports. 4 (12): 1182–9. doi:10.1038/sj.embor.7400018. PMC 1326413. PMID 14608369.
  8. Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L (Feb 2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". The Journal of Cell Biology. 156 (4): 653–64. doi:10.1083/jcb.200110081. PMC 2174079. PMID 11839770.

Further reading

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