USP15

USP15
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1W6V, 3LMN, 3PPA, 3PV1, 3T9L, 4A3O, 4A3P, 5JJW
Identifiers
Aliases	USP15, UNPH-2, UNPH4, ubiquitin specific peptidase 15
External IDs	OMIM: 604731 MGI: 101857 HomoloGene: 101542 GeneCards: USP15
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[1]
End	123,196,995 bp[1]
Gene ontology
Molecular function	• ubiquitin modification-dependent histone binding; • cysteine-type peptidase activity; • peptidase activity; • GO:0001948 protein binding; • catalytic activity; • thiol-dependent ubiquitin-specific protease activity; • identical protein binding; • transforming growth factor beta receptor binding; • cysteine-type endopeptidase activity; • SMAD binding; • hydrolase activity; • thiol-dependent ubiquitinyl hydrolase activity;
Cellular component	• cytoplasm; • cell nucleus; • cytosol; • mitochondrion;
Biological process	• pathway-restricted SMAD protein phosphorylation; • ubiquitin-dependent protein catabolic process; • monoubiquitinated protein deubiquitination; • BMP signaling pathway; • proteolysis; • histone H2B conserved C-terminal lysine deubiquitination; • transforming growth factor beta receptor signaling pathway; • protein deubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	9958
	14479
	n/a
	ENSMUSG00000020124
	Q9Y4E8
	Q8R5H1
	NM_001252078; NM_001252079; NM_006313
	NM_001301628; NM_027604
NP_001239007; NP_001239008; NP_006304; NP_001338088; NP_001338089;
	NP_001338090; NP_001338091; NP_001338092; NP_001338093; NP_001338094; NP_001338095
	NP_001288557; NP_081880
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 15 is an enzyme that in humans is encoded by the USP15 gene.[4][5]

Ubiquitin (MIM 191339), a highly conserved protein involved in the regulation of intracellular protein breakdown, cell cycle regulation, and stress response, is released from degraded proteins by disassembly of the polyubiquitin chains. The disassembly process is mediated by ubiquitin-specific proteases (USPs). Also see USP1 (MIM 603478).[supplied by OMIM][5]

References

GRCm38: Ensembl release 89: ENSMUSG00000020124 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.
"Entrez Gene: USP15 ubiquitin specific peptidase 15".

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–52. doi:10.1080/10409239891204251. PMID 9827704.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
de Jong RN, Ab E, Diercks T, et al. (2006). "Solution structure of the human ubiquitin-specific protease 15 DUSP domain". J. Biol. Chem. 281 (8): 5026–31. doi:10.1074/jbc.M510993200. PMID 16298993.
Hetfeld BK, Helfrich A, Kapelari B, et al. (2005). "The zinc finger of the CSN-associated deubiquitinating enzyme USP15 is essential to rescue the E3 ligase Rbx1". Curr. Biol. 15 (13): 1217–21. doi:10.1016/j.cub.2005.05.059. PMID 16005295.
Soboleva TA, Jans DA, Johnson-Saliba M, Baker RT (2005). "Nuclear-cytoplasmic shuttling of the oncogenic mouse UNP/USP4 deubiquitylating enzyme". J. Biol. Chem. 280 (1): 745–52. doi:10.1074/jbc.M401394200. PMID 15494318.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Angelats C, Wang XW, Jermiin LS, et al. (2003). "Isolation and characterization of the mouse ubiquitin-specific protease Usp15". Mamm. Genome. 14 (1): 31–46. doi:10.1007/s00335-002-3035-0. PMID 12532266.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Baker RT, Wang XW, Woollatt E, et al. (1999). "Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases". Genomics. 59 (3): 264–74. doi:10.1006/geno.1999.5879. PMID 10444327.
Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000020124 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12838346-4] Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.

[entrez-5] "Entrez Gene: USP15 ubiquitin specific peptidase 15".

USP15

References

Further reading