UIMC1

UIMC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MKF, 2MKG, 2RR9, 2N9E
Identifiers
Aliases	UIMC1, RAP80, X2HRIP110, ubiquitin interaction motif containing 1
External IDs	OMIM: 609433 MGI: 103185 HomoloGene: 9455 GeneCards: UIMC1
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	177,022,633 bp[1]
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)[2]
End	55,100,300 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• histone binding; • K63-linked polyubiquitin modification-dependent protein binding; • GO:0001948 protein binding;
Cellular component	• BRCA1-A complex; • cell nucleus; • nucleoplasm; • nuclear body;
Biological process	• response to ionizing radiation; • positive regulation of DNA repair; • histone H2A K63-linked deubiquitination; • negative regulation of transcription, DNA-templated; • double-strand break repair via nonhomologous end joining; • regulation of transcription, DNA-templated; • transcription, DNA-templated; • cellular response to DNA damage stimulus; • double-strand break repair; • DNA repair; • protein deubiquitination; • signal transduction involved in G2 DNA damage checkpoint; • chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	51720
	20184
	ENSG00000087206
	ENSMUSG00000025878
	Q96RL1
	Q5U5Q9
	NM_001199297; NM_001199298; NM_016290; NM_001317961
	NM_001293660; NM_011307; NM_001359757; NM_001359758
	NP_001186226; NP_001186227; NP_001304890; NP_057374
	NP_001280589; NP_035437; NP_001346686; NP_001346687
	Wikidata
View/Edit Human	View/Edit Mouse

BRCA1-A complex subunit RAP80 is a protein that in humans is encoded by the UIMC1 gene.[5][6]

References

GRCh38: Ensembl release 89: ENSG00000087206 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000025878 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Yan Z, Kim YS, Jetten AM (Aug 2002). "RAP80, a novel nuclear protein that interacts with the retinoid-related testis-associated receptor". J Biol Chem. 277 (35): 32379–88. doi:10.1074/jbc.M203475200. PMID 12080054.
"Entrez Gene: UIMC1 ubiquitin interaction motif containing 1".

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kim YS, Nakanishi G, Oudes AJ, et al. (2004). "Tsp57: a novel gene induced during a specific stage of spermatogenesis". Biol. Reprod. 70 (1): 106–13. doi:10.1095/biolreprod.103.018465. PMID 12954732.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Wang B, Matsuoka S, Ballif BA, et al. (2007). "Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response". Science. 316 (5828): 1194–8. doi:10.1126/science.1139476. PMC 3573690. PMID 17525340.
Sobhian B, Shao G, Lilli DR, et al. (2007). "RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites". Science. 316 (5828): 1198–202. doi:10.1126/science.1139516. PMC 2706583. PMID 17525341.
Kim H, Chen J, Yu X (2007). "Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response". Science. 316 (5828): 1202–5. doi:10.1126/science.1139621. PMID 17525342.
Shebzukhov YV, Koroleva EP, Khlgatian SV, et al. (2007). "RAP80/UIMC1 as cancer-associated antigen: alternative splice variants and their immunogenicity". Cancer Lett. 255 (2): 255–62. doi:10.1016/j.canlet.2007.04.013. PMID 17562356.
Yan J, Kim YS, Yang XP, et al. (2007). "The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response". Cancer Res. 67 (14): 6647–56. doi:10.1158/0008-5472.CAN-07-0924. PMC 2391092. PMID 17621610.
Yan J, Yang XP, Kim YS, et al. (2007). "RAP80 interacts with the SUMO-conjugating enzyme UBC9 and is a novel target for sumoylation". Biochem. Biophys. Res. Commun. 362 (1): 132–8. doi:10.1016/j.bbrc.2007.07.158. PMC 2049087. PMID 17698038.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000087206 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025878 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12080054-5] Yan Z, Kim YS, Jetten AM (Aug 2002). "RAP80, a novel nuclear protein that interacts with the retinoid-related testis-associated receptor". J Biol Chem. 277 (35): 32379–88. doi:10.1074/jbc.M203475200. PMID 12080054.

[entrez-6] "Entrez Gene: UIMC1 ubiquitin interaction motif containing 1".

UIMC1

References

Further reading