Toxoplasma lactate dehydrogenase 1 regulatory UTR
In Toxoplasma gondii the translational repression of lactate dehydrogenase 1 (LDH1) was discovered to be mediated through its 5′UTR. A small nucleotide regulatory RNA hairpin was shown to be essential for the repression. It is possible that this hairpin may act as the nucleation site for the binding of an trans-acting factor(s) that allow for the translational repression.[1]
| LDH1 5′UTR | |
|---|---|
 Predicted secondary structure and sequence conservation of LDH1 5′UTR | |
| Identifiers | |
| Rfam | RF02697 |
| Other data | |
| Domain(s) | Bacteria |
| GO | 0045182 |
| SO | 0005836,0000204 |
| PDB structures | PDBe |
References
- Holmes M, Itaas V, Ananvoranich S (November 2014). "Sustained translational repression of lactate dehydrogenase 1 in Toxoplasma gondii bradyzoites is conferred by a small regulatory RNA hairpin". The FEBS Journal. 281 (22): 5077–5091. doi:10.1111/febs.13048. PMID 25223457.
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