Termination factor

Termination factor is a protein signal that mediates the termination of RNA transcription by recognizing a stop codon and causing the release of the newly made mRNA. This is part of the process that regulates the transcription of RNA to preserve gene expression integrity and are present in both eukaryotes and prokaryotes, although the process in bacteria is more widely understood. [1] The most extensively studied and detailed transcriptional termination factor is the Rho (ρ) protein of E. coli. [2]

See also

References
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  2. Boudvillain M, Figueroa-Bossi N, Bossi L (April 2013). "Terminator still moving forward: expanding roles for Rho factor". Current Opinion in Microbiology. 16 (2): 118–24. doi:10.1016/j.mib.2012.12.003. PMID 23347833.
  3. Richardson JP (July 2003). "Loading Rho to terminate transcription". Cell. 114 (2): 157–9. doi:10.1016/s0092-8674(03)00554-3. PMID 12887917.
  4. Brennan CA, Dombroski AJ, Platt T (March 1987). "Transcription termination factor rho is an RNA-DNA helicase". Cell. 48 (6): 945–52. doi:10.1016/0092-8674(87)90703-3. PMID 3030561.
  5. Roberts JW (April 2019). "Mechanisms of Bacterial Transcription Termination". Journal of Molecular Biology. 431 (20): 4030–4039. doi:10.1016/j.jmb.2019.04.003. PMID 30978344.
  6. Kriner MA, Sevostyanova A, Groisman EA (August 2016). "Learning from the Leaders: Gene Regulation by the Transcription Termination Factor Rho". Trends in Biochemical Sciences. 41 (8): 690–699. doi:10.1016/j.tibs.2016.05.012. PMC 4967001. PMID 27325240.
  7. Qayyum MZ, Dey D, Sen R (April 2016). "Transcription Elongation Factor NusA Is a General Antagonist of Rho-dependent Termination in Escherichia coli". The Journal of Biological Chemistry. 291 (15): 8090–108. doi:10.1074/jbc.M115.701268. PMC 4825012. PMID 26872975.
  8. Malik M, Li L, Zhao X, Kerns RJ, Berger JM, Drlica K (December 2014). "Lethal synergy involving bicyclomycin: an approach for reviving old antibiotics". The Journal of Antimicrobial Chemotherapy. 69 (12): 3227–35. doi:10.1093/jac/dku285. PMC 4228776. PMID 25085655.
  9. Nielsen S, Yuzenkova Y, Zenkin N (June 2013). "Mechanism of eukaryotic RNA polymerase III transcription termination". Science. 340 (6140): 1577–80. Bibcode:2013Sci...340.1577N. doi:10.1126/science.1237934. PMC 3760304. PMID 23812715.
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