TUBGCP4

TUBGCP4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3RIP
Identifiers
Aliases	TUBGCP4, 76P, GCP-4, GCP4, Grip76, MCCRP3, tubulin gamma complex associated protein 4
External IDs	OMIM: 609610 MGI: 1196293 HomoloGene: 8690 GeneCards: TUBGCP4
Gene location (Human)
Chr.	Chromosome 15 (human)[1]
End	43,409,771 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	121,198,770 bp[2]
Gene ontology
Molecular function	• structural constituent of cytoskeleton; • microtubule minus-end binding; • GO:0001948 protein binding; • gamma-tubulin binding;
Cellular component	• cytoplasm; • microtubule organizing center; • gamma-tubulin complex; • cytosol; • spindle pole body; • spindle pole; • recycling endosome; • equatorial microtubule organizing center; • gamma-tubulin ring complex; • membrane; • microtubule; • microtubule cytoskeleton; • cytoskeleton; • centrosome;
Biological process	• interphase microtubule nucleation by interphase microtubule organizing center; • microtubule cytoskeleton organization; • mitotic spindle assembly; • centrosome duplication; • cytoplasmic microtubule organization; • microtubule nucleation; • meiotic cell cycle; • mitotic cell cycle; • spindle assembly; • macromolecular complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	27229
	51885
	ENSG00000137822
	ENSMUSG00000027263
	Q9UGJ1
	Q9D4F8
	NM_001286414; NM_014444
	NM_001290824; NM_153387
	NP_001273343; NP_055259
	NP_001277753; NP_700436
	Wikidata
View/Edit Human	View/Edit Mouse

Tubulin, gamma complex associated protein 4 is a protein in humans that is encoded by the TUBGCP4 gene.[5] It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

References

GRCh38: Ensembl release 89: ENSG00000137822 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000027263 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Tubulin, gamma complex associated protein 4".

Hsu HL, Yeh NH (February 1996). "Dynamic changes of NuMA during the cell cycle and possible appearance of a truncated form of NuMA during apoptosis". Journal of Cell Science. 109 ( Pt 2) (2): 277–88. PMID 8838651.
Haren L, Merdes A (May 2002). "Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules". Journal of Cell Science. 115 (Pt 9): 1815–24. PMID 11956313.
Murphy SM, Preble AM, Patel UK, O'Connell KL, Dias DP, Moritz M, Agard D, Stults JT, Stearns T (November 2001). "GCP5 and GCP6: two new members of the human gamma-tubulin complex". Molecular Biology of the Cell. 12 (11): 3340–52. doi:10.1091/mbc.12.11.3340. PMC 60259. PMID 11694571.
Fava F, Raynaud-Messina B, Leung-Tack J, Mazzolini L, Li M, Guillemot JC, Cachot D, Tollon Y, Ferrara P, Wright M (November 1999). "Human 76p: A new member of the gamma-tubulin-associated protein family". The Journal of Cell Biology. 147 (4): 857–68. doi:10.1083/jcb.147.4.857. PMC 2156165. PMID 10562286.
Takahashi M, Yamagiwa A, Nishimura T, Mukai H, Ono Y (September 2002). "Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex". Molecular Biology of the Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMC 124155. PMID 12221128.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137822 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027263 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Tubulin, gamma complex associated protein 4".

TUBGCP4

See also

References

Further reading