TUBG1

Tubulin, gamma 1 is a protein in humans that is encoded by the TUBG1 gene.[5] This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle.

TUBG1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTUBG1, CDCBM4, GCP-1, TUBG, TUBGCP1, tubulin gamma 1
External IDsOMIM: 191135 MGI: 101834 HomoloGene: 833 GeneCards: TUBG1
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q21.2Start42,609,683 bp[1]
End42,615,238 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

7283

103733

Ensembl

ENSG00000131462

ENSMUSG00000035198

UniProt

P23258

P83887

RefSeq (mRNA)

NM_001070

NM_134024

RefSeq (protein)

NP_001061

NP_598785

Location (UCSC)Chr 17: 42.61 – 42.62 MbChr 11: 101.12 – 101.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References
  1. GRCh38: Ensembl release 89: ENSG00000131462 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000035198 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Tubulin, gamma 1".

Further reading
  • Zhang X, Chen Q, Feng J, Hou J, Yang F, Liu J, Jiang Q, Zhang C (July 2009). "Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome". Journal of Cell Science. 122 (Pt 13): 2240–51. doi:10.1242/jcs.042747. PMID 19509060.
  • Lau AS, Mruk DD (April 2003). "Rab8B GTPase and junction dynamics in the testis". Endocrinology. 144 (4): 1549–63. doi:10.1210/en.2002-220893. PMID 12639940.
  • Feng Y, Olson EC, Stukenberg PT, Flanagan LA, Kirschner MW, Walsh CA (December 2000). "LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome". Neuron. 28 (3): 665–79. doi:10.1016/S0896-6273(00)00145-8. PMID 11163258.
  • Hsu LC, White RL (October 1998). "BRCA1 is associated with the centrosome during mitosis". Proceedings of the National Academy of Sciences of the United States of America. 95 (22): 12983–8. doi:10.1073/pnas.95.22.12983. PMC 23679. PMID 9789027.
  • Manning JA, Shalini S, Risk JM, Day CL, Kumar S (March 2010). Hotchin NA (ed.). "A direct interaction with NEDD1 regulates gamma-tubulin recruitment to the centrosome". PLoS One. 5 (3): e9618. doi:10.1371/journal.pone.0009618. PMC 2835750. PMID 20224777.
  • Aldaz H, Rice LM, Stearns T, Agard DA (May 2005). "Insights into microtubule nucleation from the crystal structure of human gamma-tubulin". Nature. 435 (7041): 523–7. doi:10.1038/nature03586. PMID 15917813.
  • Niu Y, Liu T, Tse GM, Sun B, Niu R, Li HM, Wang H, Yang Y, Ye X, Wang Y, Yu Q, Zhang F (April 2009). "Increased expression of centrosomal alpha, gamma-tubulin in atypical ductal hyperplasia and carcinoma of the breast". Cancer Science. 100 (4): 580–7. doi:10.1111/j.1349-7006.2008.01075.x. PMID 19215229.
  • Hampe C, Ardila-Osorio H, Fournier M, Brice A, Corti O (July 2006). "Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity". Human Molecular Genetics. 15 (13): 2059–75. doi:10.1093/hmg/ddl131. PMID 16714300.
  • Zyss D, Montcourrier P, Vidal B, Anguille C, Mérezègue F, Sahuquet A, Mangeat PH, Coopman PJ (December 2005). "The Syk tyrosine kinase localizes to the centrosomes and negatively affects mitotic progression". Cancer Research. 65 (23): 10872–80. doi:10.1158/0008-5472.CAN-05-1270. PMID 16322234.


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