TSPYL2

TSPYL2
Identifiers
Aliases	TSPYL2, CDA1, CINAP, CTCL, DENTT, HRIHFB2216, NP79, SE204, TSPX, TSPY-like 2, TSPY like 2
External IDs	OMIM: 300564 MGI: 106244 HomoloGene: 11140 GeneCards: TSPYL2
Gene location (Human)
Chr.	X chromosome (human)[1]
End	53,088,540 bp[1]
Gene location (Mouse)
Chr.	X chromosome (mouse)[2]
End	152,342,425 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• rDNA binding; • GO:0001948 protein binding;
Cellular component	• nucleolus; • nucleoplasm; • cell nucleus; • cytoplasm;
Biological process	• cell cycle; • nucleosome assembly; • IRE1-mediated unfolded protein response; • negative regulation of cell cycle; • negative regulation of DNA replication; • regulation of protein kinase activity; • regulation of transcription, DNA-templated; • regulation of signal transduction; • negative regulation of cell growth; • transcription, DNA-templated; • chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	64061
	52808
	ENSG00000184205
	ENSMUSG00000041096
	Q9H2G4
	Q7TQI8
	NM_022117
	NM_029836; NM_145936; NM_001358369
	NP_071400
	NP_084112; NP_001345298
	Wikidata
View/Edit Human	View/Edit Mouse

Testis-specific Y-encoded-like protein 2 is a protein that in humans is encoded by the TSPYL2 gene.[5][6][7]

References

GRCh38: Ensembl release 89: ENSG00000184205 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000041096 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Ozbun LL, You L, Kiang S, Angdisen J, Martinez A, Jakowlew SB (Apr 2001). "Identification of differentially expressed nucleolar TGF-beta1 target (DENTT) in human lung cancer cells that is a new member of the TSPY/SET/NAP-1 superfamily" (Submitted manuscript). Genomics. 73 (2): 179–93. doi:10.1006/geno.2001.6505. PMID 11318608.
Chai Z, Sarcevic B, Mawson A, Toh BH (Sep 2001). "SET-related cell division autoantigen-1 (CDA1) arrests cell growth". J Biol Chem. 276 (36): 33665–74. doi:10.1074/jbc.M007681200. PMID 11395479.
"Entrez Gene: TSPYL2 TSPY-like 2".

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Eichmuller S, Usener D, Dummer R, et al. (2001). "Serological detection of cutaneous T-cell lymphoma-associated antigens". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 629–34. doi:10.1073/pnas.021386498. PMC 14639. PMID 11149944.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wang GS, Hong CJ, Yen TY, et al. (2004). "Transcriptional modification by a CASK-interacting nucleosome assembly protein". Neuron. 42 (1): 113–28. doi:10.1016/S0896-6273(04)00139-4. PMID 15066269.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Santama N, Ogg SC, Malekkou A, et al. (2006). "Characterization of hCINAP, a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus". J. Biol. Chem. 280 (43): 36429–41. doi:10.1074/jbc.M501982200. PMID 16079131.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Radke JR, Donald RG, Eibs A, et al. (2006). "Changes in the expression of human cell division autoantigen-1 influence Toxoplasma gondii growth and development". PLoS Pathog. 2 (10): e105. doi:10.1371/journal.ppat.0020105. PMC 1626100. PMID 17069459.
Tu Y, Wu W, Wu T, et al. (2007). "Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21(Waf1/Cip1) by activating p53 and MEK/ERK1/2 MAPK pathways". J. Biol. Chem. 282 (16): 11722–31. doi:10.1074/jbc.M609623200. PMID 17317670.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000184205 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041096 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11318608-5] Ozbun LL, You L, Kiang S, Angdisen J, Martinez A, Jakowlew SB (Apr 2001). "Identification of differentially expressed nucleolar TGF-beta1 target (DENTT) in human lung cancer cells that is a new member of the TSPY/SET/NAP-1 superfamily" (Submitted manuscript). Genomics. 73 (2): 179–93. doi:10.1006/geno.2001.6505. PMID 11318608.

[pmid11395479-6] Chai Z, Sarcevic B, Mawson A, Toh BH (Sep 2001). "SET-related cell division autoantigen-1 (CDA1) arrests cell growth". J Biol Chem. 276 (36): 33665–74. doi:10.1074/jbc.M007681200. PMID 11395479.

[entrez-7] "Entrez Gene: TSPYL2 TSPY-like 2".

TSPYL2

References

Further reading