TRIP11

Thyroid receptor-interacting protein 11 is a protein that in humans is encoded by the TRIP11 gene.[5][6][7]

TRIP11
Identifiers
AliasesTRIP11, ACG1A, CEV14, GMAP-210, TRIP-11, TRIP230, GMAP210, thyroid hormone receptor interactor 11, ODCD
External IDsOMIM: 604505 MGI: 1924393 HomoloGene: 20897 GeneCards: TRIP11
Gene location (Human)
Chr.Chromosome 14 (human)[1]
Band14q32.12Start91,965,991 bp[1]
End92,040,896 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

9321

109181

Ensembl

ENSG00000100815

ENSMUSG00000021188

UniProt

Q15643

n/a

RefSeq (mRNA)

NM_004239
NM_001321851

NM_028446

RefSeq (protein)

NP_001308780
NP_004230

n/a

Location (UCSC)Chr 14: 91.97 – 92.04 MbChr 12: 101.83 – 101.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

TRIP11 was first identified through its ability to interact functionally with thyroid hormone receptor-beta (THRB; MIM 190160). It has also been found in association with the Golgi apparatus and microtubules.[supplied by OMIM][7]

Interactions

TRIP11 has been shown to interact with Retinoblastoma protein[8] and Thyroid hormone receptor alpha.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000100815 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021188 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (Feb 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Molecular Endocrinology. 9 (2): 243–54. doi:10.1210/me.9.2.243. PMID 7776974.
  6. Abe A, Emi N, Tanimoto M, Terasaki H, Marunouchi T, Saito H (Dec 1997). "Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution". Blood. 90 (11): 4271–7. PMID 9373237.
  7. "Entrez Gene: TRIP11 thyroid hormone receptor interactor 11".
  8. Chang KH, Chen Y, Chen TT, Chou WH, Chen PL, Ma YY, Yang-Feng TL, Leng X, Tsai MJ, O'Malley BW, Lee WH (Aug 1997). "A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein". Proceedings of the National Academy of Sciences of the United States of America. 94 (17): 9040–5. doi:10.1073/pnas.94.17.9040. PMC 23019. PMID 9256431.

Further reading


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