TLE4

Transducin-like enhancer protein 4 is a protein that in humans is encoded by the TLE4 gene.[5][6]

TLE4
Identifiers
AliasesTLE4, BCE-1, BCE1, E(spI), ESG, ESG4, GRG4, Grg-4, transducin like enhancer of split 4, TLE family member 4, transcriptional corepressor, E(spl)
External IDsOMIM: 605132 MGI: 104633 HomoloGene: 38259 GeneCards: TLE4
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q21.31Start79,571,773 bp[1]
End79,726,882 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

7091

21888

Ensembl

ENSG00000106829

ENSMUSG00000024642

UniProt

Q04727

Q62441

RefSeq (mRNA)

NM_011600
NM_001302947
NM_001302950
NM_001302951

RefSeq (protein)

NP_001289876
NP_001289879
NP_001289880
NP_035730

Location (UCSC)Chr 9: 79.57 – 79.73 MbChr 19: 14.45 – 14.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


Interactions

TLE4 has been shown to interact with PAX5.[7][8]

References

  1. GRCh38: Ensembl release 89: ENSG00000106829 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024642 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Miyasaka H, Choudhury BK, Hou EW, Li SS (August 1993). "Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein". European Journal of Biochemistry. 216 (1): 343–52. doi:10.1111/j.1432-1033.1993.tb18151.x. PMID 8365415.
  6. "Entrez Gene: TLE4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)".
  7. Eberhard D, Jiménez G, Heavey B, Busslinger M (May 2000). "Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family". The EMBO Journal. 19 (10): 2292–303. doi:10.1093/emboj/19.10.2292. PMC 384353. PMID 10811620.
  8. Milili M, Gauthier L, Veran J, Mattei MG, Schiff C (August 2002). "A new Groucho TLE4 protein may regulate the repressive activity of Pax5 in human B lymphocytes". Immunology. 106 (4): 447–55. doi:10.1046/j.1365-2567.2002.01456.x. PMC 1782747. PMID 12153506.

Further reading


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