Thrombospondin 4

THBS4
Identifiers
Aliases	THBS4, TSP4, TSP-4, thrombospondin 4
External IDs	OMIM: 600715 MGI: 1101779 HomoloGene: 20691 GeneCards: THBS4
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	80,083,287 bp[1]
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)[2]
End	92,794,818 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• heparin binding; • integrin binding; • GO:0001948 protein binding; • growth factor activity; • calcium ion binding;
Cellular component	• proteinaceous extracellular matrix; • basement membrane; • extracellular exosome; • extracellular region; • sarcoplasmic reticulum; • extracellular matrix; • endoplasmic reticulum; • extracellular; • collagen-containing extracellular matrix;
Biological process	• myoblast migration; • positive regulation of endothelial cell proliferation; • endothelial cell-cell adhesion; • response to unfolded protein; • cell adhesion; • positive regulation of neutrophil chemotaxis; • positive regulation of peptidyl-tyrosine phosphorylation; • negative regulation of angiogenesis; • tissue remodeling; • positive regulation of cell division; • response to endoplasmic reticulum stress; • regulation of tissue remodeling; • behavioral response to pain; • regulation of receptor activity; • signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	7060
	21828
	ENSG00000113296
	ENSMUSG00000021702
	P35443
	Q9Z1T2
	NM_001306212; NM_001306213; NM_001306214; NM_003248
	NM_011582
	NP_001293141; NP_001293142; NP_001293143; NP_003239
	NP_035712
	Wikidata
View/Edit Human	View/Edit Mouse

Thrombospondin-4 is a protein that in humans is encoded by the THBS4 gene.[5][6]

The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. Studies of the rat counterpart suggest that this protein may be involved in local signaling in the developing and adult nervous system.[6]

References

GRCh38: Ensembl release 89: ENSG00000113296 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000021702 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Lawler J, McHenry K, Duquette M, Derick L (Mar 1995). "Characterization of human thrombospondin-4". J Biol Chem. 270 (6): 2809–14. doi:10.1074/jbc.270.6.2809. PMID 7852353.
"Entrez Gene: THBS4 thrombospondin 4".

Arber S, Caroni P (1996). "Thrombospondin-4, an extracellular matrix protein expressed in the developing and adult nervous system promotes neurite outgrowth". J. Cell Biol. 131 (4): 1083–94. doi:10.1083/jcb.131.4.1083. PMC 2200004. PMID 7490284.
Lawler J, Duquette M, Urry L, et al. (1993). "The evolution of the thrombospondin gene family". J. Mol. Evol. 36 (6): 509–16. doi:10.1007/BF00556355. PMID 8350346.
Lawler J, Duquette M, Whittaker CA, et al. (1993). "Identification and characterization of thrombospondin-4, a new member of the thrombospondin gene family". J. Cell Biol. 120 (4): 1059–67. doi:10.1083/jcb.120.4.1059. PMC 2200072. PMID 8432726.
Newton G, Weremowicz S, Morton CC, et al. (2000). "The thrombospondin-4 gene". Mamm. Genome. 10 (10): 1010–6. doi:10.1007/s003359901149. PMID 10501972.
Carron JA, Hiscott P, Hagan S, et al. (2001). "Cultured human retinal pigment epithelial cells differentially express thrombospondin-1, -2, -3, and -4". Int. J. Biochem. Cell Biol. 32 (11–12): 1137–42. doi:10.1016/S1357-2725(00)00065-0. PMID 11137453.
Luo J, Dunn T, Ewing C, et al. (2002). "Gene expression signature of benign prostatic hyperplasia revealed by cDNA microarray analysis". Prostate. 51 (3): 189–200. doi:10.1002/pros.10087. PMID 11967953.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Congote LF, Difalco MR, Gibbs BF (2004). "The C-terminal peptide of thrombospondin-4 stimulates erythroid cell proliferation". Biochem. Biophys. Res. Commun. 324 (2): 673–8. doi:10.1016/j.bbrc.2004.09.107. PMID 15474480.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
van Doorn R, Zoutman WH, Dijkman R, et al. (2005). "Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73". J. Clin. Oncol. 23 (17): 3886–96. doi:10.1200/JCO.2005.11.353. PMID 15897551.
Stenina OI, Ustinov V, Krukovets I, et al. (2006). "Polymorphisms A387P in thrombospondin-4 and N700S in thrombospondin-1 perturb calcium binding sites". FASEB J. 19 (13): 1893–5. doi:10.1096/fj.05-3712fje. PMID 16148025.
Misenheimer TM, Mosher DF (2006). "Biophysical characterization of the signature domains of thrombospondin-4 and thrombospondin-2". J. Biol. Chem. 280 (50): 41229–35. doi:10.1074/jbc.M504696200. PMC 2219889. PMID 16246837.
Cui J, Randell E, Renouf J, et al. (2006). "Thrombospondin-4 1186G>C (A387P) is a sex-dependent risk factor for myocardial infarction: a large replication study with increased sample size from the same population". Am. Heart J. 152 (3): 543.e1–5. doi:10.1016/j.ahj.2006.06.002. PMID 16923428.
Cáceres M, Suwyn C, Maddox M, et al. (2007). "Increased cortical expression of two synaptogenic thrombospondins in human brain evolution". Cereb. Cortex. 17 (10): 2312–21. doi:10.1093/cercor/bhl140. PMID 17182969.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113296 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021702 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7852353-5] Lawler J, McHenry K, Duquette M, Derick L (Mar 1995). "Characterization of human thrombospondin-4". J Biol Chem. 270 (6): 2809–14. doi:10.1074/jbc.270.6.2809. PMID 7852353.

[entrez-6] "Entrez Gene: THBS4 thrombospondin 4".

Thrombospondin 4

References

Further reading