TFDP1

Transcription factor Dp-1 is a protein that in humans is encoded by the TFDP1 gene.[5][6][7]

TFDP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTFDP1, DP1, DRTF1, Dp-1, DILC, transcription factor Dp-1
External IDsOMIM: 189902 MGI: 101934 HomoloGene: 38276 GeneCards: TFDP1
Gene location (Human)
Chr.Chromosome 13 (human)[1]
Band13q34Start113,584,721 bp[1]
End113,641,473 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

7027

21781

Ensembl

ENSG00000198176

ENSMUSG00000038482

UniProt

Q14186

Q08639

RefSeq (mRNA)

NM_007111

NM_001291765
NM_001291766
NM_001291768
NM_009361
NM_001358991

RefSeq (protein)

NP_009042

NP_001278694
NP_001278695
NP_001278697
NP_033387
NP_001345920

Location (UCSC)Chr 13: 113.58 – 113.64 MbChr 8: 13.34 – 13.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The E2F transcription factor family (see MIM 189971) regulates the expression of various cellular promoters, particularly those involved in the cell cycle. E2F factors bind to DNA as homodimers or heterodimers in association with dimerization partner DP1. TFDP1 may be the first example of a family of related transcription factors; see TFDP2 (MIM 602160).[supplied by OMIM][7]

Interactions

TFDP1 has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000198176 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000038482 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Girling R, Partridge JF, Bandara LR, Burden N, Totty NF, Hsuan JJ, La Thangue NB (Nov 1993). "A new component of the transcription factor DRTF1/E2F". Nature. 365 (6445): 468. doi:10.1038/365468d0. PMID 8413592.
  6. Zhang Y, Venkatraj VS, Fischer SG, Warburton D, Chellappan SP (Mar 1997). "Genomic cloning and chromosomal assignment of the E2F dimerization partner TFDP gene family". Genomics. 39 (1): 95–8. doi:10.1006/geno.1996.4473. PMID 9027491.
  7. "Entrez Gene: TFDP1 transcription factor Dp-1".
  8. Sardet C, Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg RA (Mar 1995). "E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle". Proc. Natl. Acad. Sci. U.S.A. 92 (6): 2403–7. doi:10.1073/pnas.92.6.2403. PMC 42492. PMID 7892279.
  9. Suzuki M, Okuyama S, Okamoto S, Shirasuna K, Nakajima T, Hachiya T, Nojima H, Sekiya S, Oda K (Aug 1998). "A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer". Oncogene. 17 (7): 853–65. doi:10.1038/sj.onc.1202163. PMID 9780002.
  10. Wu CL, Zukerberg LR, Ngwu C, Harlow E, Lees JA (May 1995). "In vivo association of E2F and DP family proteins". Mol. Cell. Biol. 15 (5): 2536–46. doi:10.1128/mcb.15.5.2536. PMC 230484. PMID 7739537.
  11. Helin K, Wu CL, Fattaey AR, Lees JA, Dynlacht BD, Ngwu C, Harlow E (Oct 1993). "Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation". Genes Dev. 7 (10): 1850–61. doi:10.1101/gad.7.10.1850. PMID 8405995.
  12. Hijmans EM, Voorhoeve PM, Beijersbergen RL, van 't Veer LJ, Bernards R (Jun 1995). "E2F-5, a new E2F family member that interacts with p130 in vivo". Mol. Cell. Biol. 15 (6): 3082–9. doi:10.1128/mcb.15.6.3082. PMC 230539. PMID 7760804.
  13. Sørensen TS, Girling R, Lee CW, Gannon J, Bandara LR, La Thangue NB (Oct 1996). "Functional interaction between DP-1 and p53". Mol. Cell. Biol. 16 (10): 5888–95. doi:10.1128/mcb.16.10.5888. PMC 231590. PMID 8816502.

Further reading


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