TAX1BP3

Tax1-binding protein 3 is a protein that in humans is encoded by the TAX1BP3 gene.[5][6][7] This name is in reference to the Tax1 protein of the Human T-cell Lymphotropic Virus (HTLV) which was used to discover Tax1BP3 in a yeast 2-hybrid screen and subsequently verified by co-IP. TIP1, as it is also known, is a PDZ domain containing protein. However, unlike most PDZ domain proteins which act as scaffolds and often contain multiple PDZ domains as well as other protein domains, TIP1 is essentially just the PDZ domain. This has led to the speculation that TIP1 acts as an inhibitor, either acting to separate PDZ binding motifs from their normal targets or simply preventing the protein to migrate away from the cytosol.

TAX1BP3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTAX1BP3, TIP-1, TIP1, Tax1 binding protein 3
External IDsOMIM: 616484 MGI: 1923531 HomoloGene: 8749 GeneCards: TAX1BP3
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17p13.2Start3,662,895 bp[1]
End3,668,679 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

30851

76281

Ensembl

ENSG00000213977

ENSMUSG00000040158

UniProt

O14907

Q9DBG9

RefSeq (mRNA)

NM_014604
NM_001204698

NM_029564

RefSeq (protein)

NP_001191627
NP_055419

NP_083840

Location (UCSC)Chr 17: 3.66 – 3.67 MbChr 11: 73.18 – 73.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. GRCh38: Ensembl release 89: ENSG00000213977 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000040158 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–113. doi:10.1006/abio.1996.0138. PMID 8619474.
  6. Touchman JW, Anikster Y, Dietrich NL, Maduro VV, McDowell G, Shotelersuk V, Bouffard GG, Beckstrom-Sternberg SM, Gahl WA, Green ED (Mar 2000). "The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion". Genome Res. 10 (2): 165–173. doi:10.1101/gr.10.2.165. PMC 310836. PMID 10673275.
  7. "Entrez Gene: TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3".

Further reading

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