Sunflower trypsin inhibitor

Sunflower trypsin inhibitor (SFTI) is a small, circular peptide produced in sunflower seeds, and is a potent inhibitor of trypsin. It is the smallest known member of the Bowman-Birk family of serine protease inhibitors.[1]

One example of Sunflower trypsin inhibitor is Sunflower trypsin inhibitor-1 (SFTI-1). Sunflower trypsin inhibitor-1 is a potent Bowman-Birk inhibitor. Sunflower trypsin inhibitor-1 is the simplest cysteine-rich peptide scaffold because it is a bicyclic 14 amino acid peptide and only has one disulfide bond. The disulfide bond divides the peptide into two loops. One loop is a functional trypsin inhibitory and the second loop is a nonfunctional loop.[2] The nonfunctional loop can be replaced by a bioactive loop. It is extracted from a seed of a sunflower called Helianthus annuus. The synthesis of SFTI is not known however, it can evolutionarily linked to a gene-coded product from classic Bowman-Birk inhibitors.[3] STFI is used in radiopharmaceutical, antimicrobial, and pro-angiogenic peptides.[2]

See also
  • Bowman-Birk protease inhibitor

References
  1. Luckett S, Garcia RS, Barker JJ, Konarev AV, Shewry PR, Clarke AR, Brady RL (Jul 1999). "High-resolution structure of a potent, cyclic proteinase inhibitor from sunflower seeds". J Mol Biol. 290 (9): 525–33. doi:10.1006/jmbi.1999.2891. PMID 10390350.
  2. Qiu, Yibo; Taichi, Misako; Wei, Na; Yang, Huan; Luo, Kathy Qian; Tam, James P. (2017-01-12). "An Orally Active Bradykinin B 1 Receptor Antagonist Engineered as a Bifunctional Chimera of Sunflower Trypsin Inhibitor". Journal of Medicinal Chemistry. 60 (1): 504–510. doi:10.1021/acs.jmedchem.6b01011. ISSN 0022-2623.
  3. Korsinczky, Michael L. J.; Craik, Horst Joachim Schirra and David J. (2004-09-30). "Sunflower Trypsin Inhibitor-1". Current Protein & Peptide Science. doi:10.2174/1389203043379594. Retrieved 2019-12-01.


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