Spondin 1

Spondin-1 (also known as F-spondin) is a protein that in humans is encoded by the SPON1 gene.[5] It is secreted by cells of the floor plate and may be involved in axon guidance[6] The protein contains 807 amino acids and is structurally composed of six thrombospondin domains, one reelin domain, and one spondin domain.

SPON1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSPON1, VSGP/F-spondin, f-spondin, Spondin 1
External IDsOMIM: 604989 MGI: 2385287 HomoloGene: 4453 GeneCards: SPON1
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11p15.2Start13,962,723 bp[1]
End14,268,133 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10418

233744

Ensembl

ENSG00000262655

ENSMUSG00000038156

UniProt

Q9HCB6

Q8VCC9

RefSeq (mRNA)

NM_006108

NM_145584

RefSeq (protein)

NP_006099

NP_663559

Location (UCSC)Chr 11: 13.96 – 14.27 MbChr 7: 113.77 – 114.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


References

  1. GRCh38: Ensembl release 89: ENSG00000262655 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000038156 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
  6. "Entrez Gene: SPON1 spondin 1, extracellular matrix protein".

Further reading


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